3-Phenoxysulfolan | 22167-75-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-Phenoxysulfolan
• 英文别名: 3-phenoxy-tetrahydro-thiophene-1,1-dioxide；3-Phenoxy-tetrahydro-thiophen-1,1-dioxid；3-Phenoxytetrahydrothiophene 1,1-dioxide；3-phenoxythiolane 1,1-dioxide
• CAS: 22167-75-5
• 化学式: C₁₀H₁₂O₃S
• mdl: MFCD00159106
• 分子量: 212.269
• InChiKey: LALZVUZOCGQJGE-UHFFFAOYSA-N

物化性质

• 沸点：
  410.2±38.0 °C(Predicted)
• 密度：
  1.288±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-环丁烯砜 、 苯酚 在 氢氧化钾 作用下， 生成 3-Phenoxysulfolan
  参考文献：
  名称：

  DE682079

  摘要：

  公开号：

文献信息

• INHIBITORS OF ERK NUCLEAR TRANSLOCATION
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20210292338A1

  公开（公告）日：2021-09-23

  Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R 1 and R′ 1 are aryl or heteroaryl as defined herein; and R 2 and R′ 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.
• [EN] INHIBITORS OF ERK NUCLEAR TRANSLOCATION<br/>[FR] INHIBITEURS DE LA TRANSLOCATION NUCLÉAIRE D'ERK
  申请人：YEDA RES & DEV

  公开号：WO2020115744A1

  公开（公告）日：2020-06-11

  Described herein are compounds having Formula (I) or Formula (II): wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R'1 are aryl or heteroaryl as defined herein; and R 2 and R' 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula (I) or Formula (II). The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.