(2,4-Dichlorophenyl)methyl 2,5-dimethyl-1-phenylpyrrole-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (2,4-Dichlorophenyl)methyl 2,5-dimethyl-1-phenylpyrrole-3-carboxylate
• 化学式: C₂₀H₁₇Cl₂NO₂
• 分子量: 374.3
• InChiKey: MBMWBFPUDOIGIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR ANESTHESIA
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20180022698A1

  公开（公告）日：2018-01-25

  Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. Also provided are novel compounds having anesthetic effects, pharmaceutical compositions comprising the compounds, and packaged pharmaceuticals. Computer modeling of the compounds demonstrates favorable interactions with the GABA receptor type A. In addition, the compounds display reversible anesthetic effects in an animal model, with dose-response curves similar to those of known general anesthetics. GABA receptor-mediated effects are also demonstrated in a hippocampal brain slice preparation.