(Z)-2-(dimethylamino)-2-[(Z)-octadec-9-enyl]icos-11-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-2-(dimethylamino)-2-[(Z)-octadec-9-enyl]icos-11-enoic acid
• 化学式: C₄₀H₇₇NO₂
• 分子量: 604.0
• InChiKey: OFMOVWGVULBMHZ-WRBBJXAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  43
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Process for formulating an anionic agent
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US10137201B2

  公开（公告）日：2018-11-27

  Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containing particle as described herein.

  包含阴离子剂（如含脂微粒中的核酸）的制剂 配制包含阴离子剂（如核酸）的含脂微粒的方法、制备包含阴离子剂（如核酸）的含脂微粒的方法、向有需要的患者治疗递送阴离子剂的方法，其中阴离子剂被配制在本文所述的含脂微粒中。
• PROCESS FOR FORMULATING AN ANIONIC AGENT
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：EP2968149A1

  公开（公告）日：2016-01-20
• [EN] PROCESS FOR FORMULATING AN ANIONIC AGENT<br/>[FR] PROCÉDÉ DE FORMULATION D'UN AGENT ANIONIQUE
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2014153163A1

  公开（公告）日：2014-09-25

  Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containng particle as described herein.