[Bis(3-hydroxybutanoyloxy)phosphoryloxy-(3-hydroxybutanoyloxy)phosphoryl] 3-hydroxybutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [Bis(3-hydroxybutanoyloxy)phosphoryloxy-(3-hydroxybutanoyloxy)phosphoryl] 3-hydroxybutanoate
• 英文别名: [bis(3-hydroxybutanoyloxy)phosphoryloxy-(3-hydroxybutanoyloxy)phosphoryl] 3-hydroxybutanoate
• 化学式: C₁₆H₂₈O₁₅P₂
• 分子量: 522.3
• InChiKey: VPFIVLWWXUFXGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  33
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  230
• 氢给体数：
  4
• 氢受体数：
  15

文献信息

• MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY FORMATE ASSIMILATION
  申请人：Genomatica, Inc.

  公开号：US20150050708A1

  公开（公告）日：2015-02-19

  Provided herein are non-naturally occurring microbial organisms having a formaldehyde fixation pathway and a formate assimilation pathway, which can further include a methanol metabolic pathway, a methanol oxidation pathway, a hydrogenase and/or a carbon monoxide dehydrogenase. These microbial organisms can further include a butadiene, 1,3-butanediol, crotyl alcohol or 3-buten-2-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 1,3-butanediol, crotyl alcohol or 3-buten-2-ol.

  本文提供了一些非自然产生的微生物有甲醛固定途径和甲酸同化途径，这些微生物还可以包括甲醇代谢途径、甲醇氧化途径、氢化酶和/或一氧化碳脱氢酶。这些微生物还可以包括丁二烯、1,3-丁二醇、巴豆醇或3-丁烯-2-醇途径。此外，还提供了使用这些微生物生产丁二烯、1,3-丁二醇、巴豆醇或3-丁烯-2-醇的方法。
• Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
  申请人：GENOMATICA, INC.

  公开号：US10808262B2

  公开（公告）日：2020-10-20

  The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

  本发明提供了含有酶途径和/或代谢修饰的非天然微生物，用于通过乙酰-CoA 提高碳通量。在某些实施方案中，具有此类途径的微生物还包括产生还原当量、甲醛固定和/或甲酸同化的途径。在某些实施方案中，通过乙酰-CoA 增强的碳通量与产生还原当量、甲醛固定和/或甲酸同化的途径相结合，可用于生产生物衍生化合物。因此，在某些实施方案中，本发明的微生物有机体可以包括能够产生本发明生物衍生化合物的途径。本发明还进一步提供了一种由本发明微生物生物体生产的生物衍生化合物、具有本发明生物衍生化合物的培养基、具有本发明生物衍生化合物的组合物、包含本发明生物衍生化合物的生物基产品，以及生产本发明生物衍生化合物的工艺。
• MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS
  申请人：Genomatica, Inc.

  公开号：EP3077501B1

  公开（公告）日：2021-07-28
• [EN] MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY FORMATE ASSIMILATION<br/>[FR] MICRO-ORGANISMES ET PROCÉDÉS DE PRODUCTION DE BUTADIÈNE ET DE COMPOSÉS ASSOCIÉS PAR ASSIMILATION DE FORMIATE
  申请人：GENOMATICA INC

  公开号：WO2014152434A2

  公开（公告）日：2014-09-25

  Provided herein are non-naturally occurring microbial organisms having a FaldFP, a FAP and/or metabolic modifications which can further include a MMP, a MOP, a hydrogenase and/or a CODH. These microbial organisms can further include a butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol.
• [EN] MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS<br/>[FR] MICROORGANISMES ET PROCÉDÉS POUR AMÉLIORER LES RENDEMENTS DE PRODUITS SUR LE MÉTHANOL FAISANT APPEL À LA SYNTHÈSE DE L'ACÉTYL-COA
  申请人：GENOMATICA INC

  公开号：WO2015084633A1

  公开（公告）日：2015-06-11

  The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.