(3-methoxyphenyl) (2S)-2-aminopropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3-methoxyphenyl) (2S)-2-aminopropanoate
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.21
• InChiKey: NYGCUHZMBLXSOY-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD FOR SYNTHESIZING NOVEL CHIRAL LIGAND, METAL CHELATE, A VARIETY OF NON-NATURAL AMINO ACIDS, MARAVIROC AND KEY INTERMEDIATE THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP3521274A1

  公开（公告）日：2019-08-07

  Disclosed is a method for synthesizing a novel chiral ligand, a metal chelate, a variety of non-natural amino acids, Maraviroc and a key intermediate thereof. In the invention, (R)-2-methyl proline is selected and used as a starting raw material, (S)-β3-amino acid is obtained by asymmetric resolution induced by using a nickel chelate, and Maraviroc is synthesized by using (S)-3-amino-3-phenylpropionic acid as a key intermediate with a high yield and the ee value reaching 98.2% or more. The method of the present invention has widely available materials, mild synthetic process conditions, is easy to control, and produces a product of a high optical purity.

  本发明公开了一种合成新型手性配体、金属螯合物、多种非天然氨基酸、马拉维若及其关键中间体的方法。本发明选择(R)-2-甲基脯氨酸作为起始原料，利用镍螯合物诱导不对称解析得到(S)-β3-氨基酸，以(S)-3-氨基-3-苯基丙酸为关键中间体合成马拉韦罗，收率高，ee值达到98.2%以上。本发明方法原料来源广泛，合成工艺条件温和，易于控制，生产的产品光学纯度高。
• Method for synthesizing novel chiral ligand, metal chelate, a variety of non-natural amino acids, maraviroc and key intermediate thereof
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US10875883B2

  公开（公告）日：2020-12-29

  Disclosed is a method for synthesizing a novel chiral ligand, a metal chelate, a variety of non-natural amino acids, Maraviroc and a key intermediate thereof. In the invention, (R)-2-methyl proline is selected and used as a starting raw material, (S)-β3-amino acid is obtained by asymmetric resolution induced by using a nickel chelate, and Maraviroc is synthesized by using (S)-3-amino-3-phenylpropionic acid as a key intermediate with a high yield and the ee value reaching 98.2% or more. The method of the present invention has widely available materials, mild synthetic process conditions, is easy to control, and produces a product of a high optical purity.

  本发明公开了一种合成新型手性配体、金属螯合物、多种非天然氨基酸、马拉维若及其关键中间体的方法。本发明选择(R)-2-甲基脯氨酸作为起始原料，利用镍螯合物诱导不对称解析得到(S)-β3-氨基酸，以(S)-3-氨基-3-苯基丙酸为关键中间体合成马拉韦罗，收率高，ee值达到98.2%以上。本发明方法原料来源广泛，合成工艺条件温和，易于控制，生产的产品光学纯度高。
• BISPECIFIC ANTIBODIES AND USES THEREOF
  申请人：The California Institute for Biomedical Research

  公开号：EP2970505A1

  公开（公告）日：2016-01-20
• CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF
  申请人：The California Institute for Biomedical Research

  公开号：EP3057991A1

  公开（公告）日：2016-08-24
• [EN] BISPECIFIC ANTIBODIES AND USES THEREOF<br/>[FR] ANTICORPS BISPÉCIFIQUES ET LEURS UTILISATIONS
  申请人：CALIFORNIA INST BIOMEDICAL RES

  公开号：WO2014153002A1

  公开（公告）日：2014-09-25

  Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co- receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.