(E,2S,3S)-3-hydroxy-2-(phenylmethoxycarbonylamino)octadec-4-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E,2S,3S)-3-hydroxy-2-(phenylmethoxycarbonylamino)octadec-4-enoic acid
• 化学式: C₂₆H₄₁NO₅
• 分子量: 447.6
• InChiKey: HRGXAPXJMICKKA-CQZHKHQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  32
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NOVEL COMPOUNDS
  申请人：Avanti Polar Lipids Inc.

  公开号：EP2970113A1

  公开（公告）日：2016-01-20
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：AVANTI POLAR LIPIDS INC

  公开号：WO2014153147A1

  公开（公告）日：2014-09-25

  Disclosed are compounds of the general formula I and II (as further defined herein) are useful in the production of inhibitors of sphingolipid synthesis the production of sphingolipids. Suitable sphingolipids, include, but not limited to, sphingosine and compounds incorporating sphingosine or that may use sphingosine as an intermediate or a starting material in their synthesis (including, but not limited to, sphingosine-1-P, ceramide, gangliosides and sphigomyelin). In one contemplated use, compounds of the general formula I and II are useful in the production of sphingosine. In another contemplated use, compounds of the general formula I and II are useful in the production of a sphingofugin. Methods of manufacturing each of the above compounds are also provided.