methyl 4,6a-bis(hydroxymethyl)-4,11b-dimethyl-7-oxo-2,3,4a,5,6,8,11,11a-octahydro-1H-cyclohepta[a]naphthalene-9-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 4,6a-bis(hydroxymethyl)-4,11b-dimethyl-7-oxo-2,3,4a,5,6,8,11,11a-octahydro-1H-cyclohepta[a]naphthalene-9-carboxylate
• 化学式: C₂₁H₃₂O₅
• 分子量: 364.5
• InChiKey: DMDRSQAGBABGRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SYNTHESIS OF GALANAL COMPOUNDS AND ANALOGUES THEREOF
  申请人：Academia Sinica

  公开号：US20140350288A1

  公开（公告）日：2014-11-27

  The present disclosure provides methods of preparing glucagon-like peptide-1 (GLP-1) receptor modulators, such as compounds of Formula (II) or (VI), or intermediates thereof. The compounds that may be prepared by the described methods are useful for regulating blood glucose levels and/or treating a disease mediated by a GLP-1 receptor (e.g., diabetes).