2-pyridyl-Pyr-N(Ph(3-F))Phg(2-Cl)-Unk

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-pyridyl-Pyr-N(Ph(3-F))Phg(2-Cl)-Unk
• 英文别名: (2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-N-(3-fluorophenyl)-5-oxo-1-pyridin-2-ylpyrrolidine-2-carboxamide
• 化学式: C₂₈H₂₄ClF₃N₄O₃
• 分子量: 557.0
• InChiKey: BNMZIPHBCZHHSG-DHLKQENFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Therapeutically active compounds and their methods of use
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US10717764B2

  公开（公告）日：2020-07-21

  Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

  本发明提供了治疗以存在 IDH1/2 突变等位基因为特征的癌症的方法，包括向有需要的受试者施用本文所述的化合物。
• THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US20190023737A1

  公开（公告）日：2019-01-24

  Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.