(2R)-2-(butylsulfonylamino)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-(butylsulfonylamino)propanoic acid
• 化学式: C₇H₁₅NO₄S
• 分子量: 209.27
• InChiKey: OZSRHFORCGVPJI-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 1, 3, Diamino-2-Hydroxypropane Pro-Drug Derivatives
  申请人：Fobian Yvette M.

  公开号：US20080161325A1

  公开（公告）日：2008-07-03

  The present invention relates to compounds of formula (AA) (I) and (X): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

  本发明涉及公式（AA）（I）和（X）的化合物，用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶酶的抑制剂，对治疗阿尔茨海默病和其他哺乳动物中A beta肽沉积的疾病具有用处。本发明的化合物适用于制备药物组合物和治疗方法，以减少A beta肽的形成。
• 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP1534693A2

  公开（公告）日：2005-06-01
• US7294642B2
  申请人：——

  公开号：US7294642B2

  公开（公告）日：2007-11-13
• [EN] 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES<br/>[FR] DERIVES DE PROMEDICAMENTS A BASE DE 1, 3-DIAMINO-2-HYDROXYPROPANE
  申请人：ELAN PHARM INC

  公开号：WO2004022523A2

  公开（公告）日：2004-03-18

  The present invention relates to compounds of formula (AA), (I) and (X), useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.