2-[(6,7-dimethoxy-4-oxo-3H-quinazolin-2-yl)methyl-ethylamino]-N-(4-sulfamoylphenyl)acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(6,7-dimethoxy-4-oxo-3H-quinazolin-2-yl)methyl-ethylamino]-N-(4-sulfamoylphenyl)acetamide
• 化学式: C₂₁H₂₅N₅O₆S
• 分子量: 475.5
• InChiKey: KMCXOTIQDLREIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  161
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Antiviral Drugs for Treatment or Prevention of Dengue Infection
  申请人：Byrd Chelsea M.

  公开号：US20100189685A1

  公开（公告）日：2010-07-29

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• Antiviral Drugs for Treatement or Prevention of Dengue Infection
  申请人：Siga Technologies Inc.

  公开号：US20130303491A1

  公开（公告）日：2013-11-14

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• ANTIVIRAL DRUGS FOR TREATMENT OR PREVENTION OF DENGUE INFECTION
  申请人：Siga Technologies, Inc.

  公开号：US20160250233A1

  公开（公告）日：2016-09-01

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• US8518960B2
  申请人：——

  公开号：US8518960B2

  公开（公告）日：2013-08-27
• US9353051B2
  申请人：——

  公开号：US9353051B2

  公开（公告）日：2016-05-31