Cyclopentan-1,2,3,4-tetracarboximid | 15774-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Cyclopentan-1,2,3,4-tetracarboximid
• 英文别名: Cyclopentan-tetracarbonsaeure-(1,2,3,4)-diimid-(1,2,3,4)；Cyclopentantetracarbonsaeure-diimid；Cyclopentantetracarboximid；tetrahydro-cyclopenta[1,2-c;3,4-c']dipyrrole-1,3,4,6-tetraone；tetrahydro-1H-cyclopenta[1,2-c:3,4-c']dipyrrole-1,3,4,6(2H,3aH,5H)-tetrone；4,10-diazatricyclo[6.3.0.02,6]undecane-3,5,9,11-tetrone
• CAS: 15774-55-7
• 化学式: C₉H₈N₂O₄
• 分子量: 208.174
• InChiKey: AMJZQQATTVRDKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  92.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,2,3,4-环戊四羧酸二酐 在 ammonium hydroxide 作用下， 生成 Cyclopentan-1,2,3,4-tetracarboximid
  参考文献：
  名称：

  苯马来酰亚胺光加合物米丁domide的同类和前药的合成作为潜在的抗肿瘤剂。2。

  摘要：

  通过几种不同的方法合成了高度不溶的二酰亚胺抗肿瘤剂米坦度胺（1b）的潜在前药。米线度胺和甲醛之间的缩合反应可干净地得到稳定的双（羟甲基）化合物7a，该化合物部分溶于水（约0.8％），并在P-388筛查中显示出改进的活性。当该化合物用仲胺处理时，可以分离出高收率的曼尼希碱。来自N-甲基哌嗪的化合物（7b）具有优异的性能，可用于临床试验。与其他醛的缩合要么没有反应，要么没有活性差的化合物。由7a和琥珀酸酐制备水溶性酯，但是效力和活性降低。1a的双键与臭氧的氧化产生了惰性二酸，而二氢化合物的活性与烯烃相同。当用马来酰亚胺光解其它芳族化合物（苯甲醚，对二甲苯，均三甲苯）时，发现所得的光产物是无活性的。由相应的酸酐合成了来自其他环系统的二酰亚胺，发现它们是无活性的。然而，这些（12a）之一的双（羟甲基）衍生物在P-388筛选中是有活性的。

  DOI：

  10.1021/jm00161a006

文献信息

• Modifiable polyunsaturated polymers and processes for their preparation
  申请人：Parthiban Anbanandam

  公开号：US20060189774A1

  公开（公告）日：2006-08-24

  The present invention relates to modifiable linear polyunsaturated polymers and processes for preparing the same comprising reacting solely at least one bifunctional nucleophilic compound with at least one α-functional unsaturated monomer. The at least one bifunctional nucleophilic compound of the invention comprises two nucleophiles independently selected from the group consisting of C, N, O, S and Se. The at least one α-functional unsaturated monomer of the invention comprises two leaving groups L 1 and L 2 , wherein at least one of the leaving groups L 1 and L 2 of the at least one α-functional unsaturated monomer is part of the nonaromatic unsaturated structure C═C—C α -L. The double bond of said α-functional unsaturated monomer is maintained in the polyunsaturated polymer.

  本发明涉及可改性线性多不饱和聚合物以及制备该聚合物的工艺，包括仅使至少一种双官能团亲核化合物与至少一种α官能团不饱和单体反应。本发明的至少一种双官能团亲核化合物包括两个独立选自 C、N、O、S 和 Se 组的亲核物。本发明的至少一种 α-官能团不饱和单体包括两个离去基团 L 1 和 L 2 其中至少一个离去基团 L 1 和 L 2 的至少一个离去基团 L 1 和 L 2 是非芳香族不饱和结构 C═C-C α -L.所述 α-官能团不饱和单体的双键保留在多不饱和聚合物中。
• DEUTSCH H. M.; GELBAUM L. T.; MCLAUGHLIN M.; FLEISCHMANN T. J.; EARNHART +, J. MED. CHEM., 29,(1986) N 11, 2164-2170
  作者：DEUTSCH H. M.、 GELBAUM L. T.、 MCLAUGHLIN M.、 FLEISCHMANN T. J.、 EARNHART +

  DOI：——

  日期：——
• GAS SEPARATION COMPOSITE MEMBRANE AND METHOD OF PRODUCING THE SAME, AND GAS SEPARATING MODULE, GAS SEPARATION APPARATUS AND GAS SEPARATION METHOD USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20140130667A1

  公开（公告）日：2014-05-15

  A gas separation composite membrane, containing a gas-permeable supporting layer and a gas separating layer containing a crosslinked polyimide resin over the gas-permeable supporting layer, in which the crosslinked polyimide resin is formed by a polyimide compound being crosslinked by a radically crosslinkable functional group thereof, and a ratio [η] of a crosslinked site to an imide group of the polyimide compound (the number of crosslinked sites/the number of imide groups) in the crosslinked polyimide resin is 0.0001 or more and 0.45 or less; a method of producing the same; and a gas separating module, a gas separation apparatus and a gas separation method using the same.
• GAS SEPARATION COMPOSITE MEMBRANE, METHOD OF PRODUCING THE SAME, GAS SEPARATING MODULE USING THE SAME, AND GAS SEPARATION APPARATUS AND GAS SEPARATION METHOD
  申请人：FUJIFILM CORPORATION

  公开号：US20140352534A1

  公开（公告）日：2014-12-04

  A gas separation composite membrane, containing: a gas-permeable supporting layer; and a gas separating layer containing a crosslinked polyimide resin, over the gas-permeable supporting layer, in which the crosslinked polyimide resin is composed of a polyimide compound having been crosslinked through an ester linking group, in which the polyimide compound contains a repeating unit of formula (I), a repeating unit of formula (II-a) or (II-b), and a repeating unit of formula (III-a) or (III-b), and in which a ratio [κ] of a site forming a crosslinked chain mediated by the ester linking group to an imide group (the number of specific crosslinkable sites/the number of imide groups) is more than 0.4 and less than 0.5.
• GAS SEPARATION COMPOSITE MEMBRANE, GAS SEPARATION MODULE, GAS SEPARATION APPARATUS, GAS SEPARATION METHOD, AND METHOD OF PRODUCING GAS SEPARATION COMPOSITE MEMBRANE
  申请人：FUJIFILM Corporation

  公开号：US20150265964A1

  公开（公告）日：2015-09-24

  A gas separation composite membrane, containing a gas permeable supporting layer, and a gas separating layer containing a crosslinked polyimide resin above the gas permeable supporting layer, in which the crosslinked polyimide resin has a structure in which 2 to 4 molecules of a polyimide compound is coordinated with a divalent to tetravalent central metal via an oxygen atom or a sulfur atom, and when the crosslinked polyimide resin has plural central metals, the plural central metals are linked via the polyimide chain of the polyimide compound; and a gas separating module, a gas separation apparatus and a gas separation method utilizing this gas separation composite membrane.