Cyclopentanecarboxylic acid, 3-amino-1-methyl-, methyl ester, (1R,3S)- | 1311147-72-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cyclopentanecarboxylic acid, 3-amino-1-methyl-, methyl ester, (1R,3S)-
• 英文别名: methyl (1R,3S)-3-amino-1-methylcyclopentane-1-carboxylate
• CAS: 1311147-72-4
• 化学式: C₈H₁₅NO₂
• 分子量: 157.21
• InChiKey: DYXKGUVHXWEDTR-POYBYMJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3114128A1

  公开（公告）日：2017-01-11
• [EN] NOVEL 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION<br/>[FR] NOUVELLES HÉTEROARYLDIHYDROPYRIMIDINES CONDENSÉES EN POSITION 6 POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION À VIRUS DE L'HÉPATITE B
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015132276A1

  公开（公告）日：2015-09-11

  The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds. These compounds useful for therapy and/or prophylaxis in a human, and in particular to Hepatitis B virus (HBV) inhibitors by targeting on HBV capsid for the treatment of HBV infection.