3'-bromo-3,5-difluoro-1,1'-biphenyl | 1443351-14-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3'-bromo-3,5-difluoro-1,1'-biphenyl
• 英文别名: 3-Bromo-3',5'-difluorobiphenyl；1-(3-bromophenyl)-3,5-difluorobenzene
• CAS: 1443351-14-1
• 化学式: C₁₂H₇BrF₂
• 分子量: 269.088
• InChiKey: HSYFVTBVEXFSOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3'-bromo-3,5-difluoro-1,1'-biphenyl 在 bis-triphenylphosphine-palladium(II) chloride 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium acetate 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 34.0h， 生成 ethyl 4-(1-(benzyloxy)-5-(3',5'-difluoro-[1,1'-biphenyl ]-3-yl)-1H-pyrazol-4-yl)piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR PRESERVING AND/OR RESTORING NEURAL FUNCTION
  [FR] COMPOSITIONS ET PROCÉDÉS DE PRÉSERVATION ET/OU DE RESTAURATION DE LA FONCTION NEURALE

  摘要：

  Provided herein are compounds of Formula I and pharmaceutically acceptable salts and compositions thereof. The compounds of the invention are useful for inhibiting 5-subunit- containing y-aminobutyric acid receptors (SGABAARS). Also disclosed herein are methods of using the compounds of the invention to decrease tonic inhibition in a neurons, treating or preventing brain or spinal cord damage (such as, for example, those caused by trauma, stroke, or neurodegenerative disease), and improving functional recovery after stroke.

  公开号：

  WO2023086603A1

文献信息

• [EN] COMPOSITIONS AND METHODS FOR PRESERVING AND/OR RESTORING NEURAL FUNCTION<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRÉSERVATION ET/OU DE RESTAURATION DE LA FONCTION NEURALE
  申请人：[en]THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：WO2023086603A1

  公开（公告）日：2023-05-19

  Provided herein are compounds of Formula I and pharmaceutically acceptable salts and compositions thereof. The compounds of the invention are useful for inhibiting 5-subunit- containing y-aminobutyric acid receptors (SGABAARS). Also disclosed herein are methods of using the compounds of the invention to decrease tonic inhibition in a neurons, treating or preventing brain or spinal cord damage (such as, for example, those caused by trauma, stroke, or neurodegenerative disease), and improving functional recovery after stroke.