4-dimethylamino-6-ethyl-anthranilic acid | 1187568-96-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-dimethylamino-6-ethyl-anthranilic acid
• 英文别名: 2-Amino-4-(dimethylamino)-6-ethylbenzoic acid；2-amino-4-(dimethylamino)-6-ethylbenzoic acid
• CAS: 1187568-96-2
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: JIAGIBBJQCVKNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-dimethylamino-6-ethyl-anthranilic acid 、 2-(4-甲基-1-哌嗪基)-3-吡啶羧酸 在 二-1H-吡咯-1-基甲酮 作用下， 以 乙腈 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

  摘要：

  The hit-to-lead optimization of the HNE inhibitor 5-methyl-2-(2-phenoxy-pyridin-3-yl)-benzo[d][1,3]oxazin-4-one is described. A structure-activity relationship study that focused on the 5 and 7 benzoxazinone positions yielded the optimized 5-ethyl-7-methoxy-benzo[d][1,3]oxazin-4-one core structure. 2-[2-(4Methyl-piperazin-1-yl)-pyridin-3-yl] derivatives of this core were shown to yield HNE inhibitors of similar potency with significantly different stabilities in rat plasma. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.053
• 作为产物：
  描述：

  在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 4-dimethylamino-6-ethyl-anthranilic acid
  参考文献：
  名称：

  Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

  摘要：

  The hit-to-lead optimization of the HNE inhibitor 5-methyl-2-(2-phenoxy-pyridin-3-yl)-benzo[d][1,3]oxazin-4-one is described. A structure-activity relationship study that focused on the 5 and 7 benzoxazinone positions yielded the optimized 5-ethyl-7-methoxy-benzo[d][1,3]oxazin-4-one core structure. 2-[2-(4Methyl-piperazin-1-yl)-pyridin-3-yl] derivatives of this core were shown to yield HNE inhibitors of similar potency with significantly different stabilities in rat plasma. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.053

文献信息

• [EN] DYE COMPOSITION USING AT LEAST ONE OXIDATION BASE AND AT LEAST ONE PARTICULAR AMINOBENZENE COUPLER, PROCESSES AND DEVICE<br/>[FR] COMPOSITION COLORANTE UTILISANT AU MOINS UNE BASE D'OXYDATION ET AU MOINS UN COUPLEUR D'AMINOBENZÈNE SPÉCIFIQUE, PROCÉDÉS ET DISPOSITIF
  申请人：OREAL

  公开号：WO2017050994A1

  公开（公告）日：2017-03-30

  The present invention relates to a composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising one or more oxidation bases and one or more particular aminobenzene couplers. The invention also relates to a process for dyeing keratin fibres using said composition in the presence of one or more chemical oxidizing agents, and to a multi-compartment device suitable for using said dye composition.