1-[Amino-[3-[2-chloro-4-(trifluoromethoxy)phenoxy]propoxyamino]methylidene]-2-propan-2-ylguanidine | 701976-24-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[Amino-[3-[2-chloro-4-(trifluoromethoxy)phenoxy]propoxyamino]methylidene]-2-propan-2-ylguanidine
• 英文别名: 1-[amino-[3-[2-chloro-4-(trifluoromethoxy)phenoxy]propoxyamino]methylidene]-2-propan-2-ylguanidine
• CAS: 701976-24-1
• 化学式: C₁₅H₂₁ClF₃N₅O₃
• 分子量: 411.81
• InChiKey: NDJYKXNKFMMXEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Biguanide and dihydrotriazine derivatives
  申请人：——

  公开号：US20040116428A1

  公开（公告）日：2004-06-17

  Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.

  本文披露了biguanide和二氢三嗪衍生物，最好是从羟胺衍生的取代不对称亚胺二碳酰胺二酰胺，以及含有biguanide和二氢三嗪衍生物的组合物。此外，本文还披露了使用biguanide和二氢三嗪衍生物的方法，包括作为抗微生物剂的方法，以及使用二氢三嗪衍生物进行生物测定的方法。还披露了制备biguanide和二氢三嗪衍生物的方法。
• [EN] BIGUANIDE AND DIHYDROTRIAZINE DERIVATIVES<br/>[FR] DERIVES DE BIGUANIDE DE D'HYDROTRIAZINE
  申请人：JACOBUS PHARMACEUTICAL COMPANY

  公开号：WO2004048320A1

  公开（公告）日：2004-06-10

  Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.

  本文披露了biguanide和dihydrotriazine衍生物，其中首选的是从羟胺衍生的取代不对称imidodicarbonimidic二酰胺，以及含有biguanide和dihydrotriazine衍生物的组合物。此外，本文还披露了使用biguanide和dihydrotriazine衍生物的方法，包括作为抗微生物剂的方法，以及使用dihydrotriazine衍生物进行生物测定的方法。本文还披露了制备biguanide和dihydrotriazine衍生物的方法。
• BIGUANIDE AND DIHYDROTRIAZINE DERIVATIVES
  申请人：Jacobus David P.

  公开号：US20080176852A1

  公开（公告）日：2008-07-24

  Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.

  本发明公开了一种大双胍和二氢三嗪衍生物，其中优选的是来自羟胺的取代不对称亚氨基碳酰亚胺二酰胺，以及含有大双胍和二氢三嗪衍生物的组合物。此外，还公开了使用大双胍和二氢三嗪衍生物的方法，包括作为抗微生物剂的方法以及使用二氢三嗪衍生物进行生物测定的方法。还公开了制备大双胍和二氢三嗪衍生物的方法。
• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• BIGUANIDE DERIVATIVES
  申请人：JACOBUS PHARMACEUTICAL CO. INC.

  公开号：EP1565430B1

  公开（公告）日：2010-02-17