Glumitocin | 10052-67-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glumitocin
• 英文别名: (2S)-2-[[(2S)-1-[(2R)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-N-(2-amino-2-oxoethyl)pentanediamide
• CAS: 10052-67-2
• 化学式: C₄₀H₆₂N₁₂O₁₃S₂
• 分子量: 983.1
• InChiKey: OAQPLDRHJAFJSE-YXEOJCNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  67
• 可旋转键数：
  28
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  422
• 氢给体数：
  15
• 氢受体数：
  16

文献信息

• TREATING DIABETES WITH OXYTOCIN OR OXYTOCIN ANALOGS
  申请人：Cai Dongsheng

  公开号：US20140066373A1

  公开（公告）日：2014-03-06

  Methods are provided of treating or preventing diabetes in a subject comprising administering to the subject an amount of oxytocin or an oxytocin analog. Methods are also provided of increasing insulin secretion in a subject comprising administering to the subject an amount of oxytocin or an oxytocin analog.
• [EN] USE OF OXYTOCIN OR OXYTOCIN ANALOGUES TO TREAT OBESITY AND DIABETES<br/>[FR] UTILISATION D'OXYTOCINE OU D'ANALOGUES D'OXYTOCINE POUR TRAITER L'OBÉSITÉ ET LE DIABÈTE
  申请人：EINSTEIN COLL MED

  公开号：WO2012161746A1

  公开（公告）日：2012-11-29

  Methods and compositions for treating obesity or an obesity comorbidity in a subject are provided, employing an inhibitor of synaptotagmin-4 or an amount of oxytocin or an analogue thereof. Methods and compositions for effecting weight gain in a subject are also provided employing synaptotagmin-4, or an analogue of synaptotagmin-4, or an oxytocin antagonist.