3-Hydroxyhexadecanoyl-coenzyme A | 35106-50-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxyhexadecanoyl-coenzyme A
• 英文别名: S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-hydroxyhexadecanethioate
• CAS: 35106-50-4
• 化学式: C₃₇H₆₆N₇O₁₈P₃S
• 分子量: 1021.9
• InChiKey: DEHLMTDDPWDRDR-QTFKDKGUSA-N

物化性质

• 密度：
  1.58±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  66
• 可旋转键数：
  34
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  409
• 氢给体数：
  10
• 氢受体数：
  23

文献信息

• US4491631A
  申请人：——

  公开号：US4491631A

  公开（公告）日：1985-01-01
• US9673030B2
  申请人：——

  公开号：US9673030B2

  公开（公告）日：2017-06-06
• [EN] PRODUCTION OF ADVANCED FUELS AND OF CHEMICALS BY YEASTS ON THE BASIS OF SECOND GENERATION FEEDSTOCKS<br/>[FR] PRODUCTION DE CARBURANTS AVANCÉS ET DE PRODUITS CHIMIQUES PAR DES LEVURES SELON LE CONCEPT DE BIOCARBURANTS DE DEUXIÈME GÉNÉRATION
  申请人：ABENGOA BIOENERGIA NUEVAS TECNOLOGIAS SA

  公开号：WO2014207087A1

  公开（公告）日：2014-12-31

  The present invention relates to modified eukaryotic microbial cells that have been engineered for producing fermentation products such as fatty acids, 1-alcohols, β- keto-acids and -alcohols, β-hydroxyacids, 1,3-diols, trans-Δ2-fatty acids, alkenes, alkanes and derivatives thereof, from second generation feedstocks, including at least pentoses. To this end the eukaryotic microbial cells have been modified to express enzymes of the fatty acid β-oxidation cycle in the cytosol of the cell in the absence of fatty acids and in the presence of a carbon source containing pentoses. The cells are further modified to express enzymes for metabolizing pentose like xylose and arabinose, as well as to express a metabolic route for producing under oxic conditions, acetyl-CoA from the non- fatty acid carbon source to feed into and drive the β-oxidation cycle in the bio synthetic direction and, to express termination enzymes for conversion of reaction β-oxidation cycle intermediates into the desired fermentation product. The invention further relates to oxic processes wherein the cells are used to produce fermentation products such as fatty acids, 1-alcohols, β-keto-acids and -alcohols, β- hydroxyacids, 1,3-diols, trans-Δ2-fatty acids, alkenes, alkanes or derivatives thereof.
• [EN] Anoxic biological production of fuels and of bulk chemicals from second generation feedstocks<br/>[FR] PRODUCTION BIOLOGIQUE ANOXIQUE DE CARBURANTS ET DE PRODUITS CHIMIQUES EN VRAC À PARTIR DE MATIÈRES PREMIÈRES DE DEUXIÈME GÉNÉRATION
  申请人：ABENGOA BIOENERGIA NUEVAS TECNOLOGIAS SA

  公开号：WO2014207099A1

  公开（公告）日：2014-12-31

  The present invention relates to modified eukaryotic microbial cells that have been engineered for producing fermentation products such as fatty acids, 1-alcohols alkenes, alkanes and derivatives thereof under anoxic conditions from second generation feedstocks, including at least pentoses. To this end the eukaryotic microbial cells have been modified to express enzymes of the fatty acid β-oxidation cycle in the cytosol of the cell,under anoxic conditions,in the absence of fatty acids and in the presence of a carbon source containing pentoses. The cells are further modified to express enzymes for metabolizing pentose like xylose and arabinose, as well as to express a metabolic route for producing under anoxic conditions, acetyl-CoA from the non-fatty acid carbon source to feed into and drive the β-oxidation cycle in the biosynthetic direction and,to express termination enzymes for conversion of reaction β-oxidation cycle intermediates into the desired fermentation product. The invention further relates to anoxic processes wherein the cells are used to produce fermentation products such as fatty acids, 1-alcohols,alkenes, alkanes or derivatives thereof.
• [EN] YEASTS ENGINEERED FOR THE PRODUCTION OF VALUABLE CHEMICALS FROM SUGARS<br/>[FR] LEVURES TECHNIQUEMENT CONÇUES POUR LA PRODUCTION DE SUBSTANCES CHIMIQUES DE VALEUR À PARTIR DE SUCRES
  申请人：ABENGOA BIOENERGIA NUEVAS TECNOLOGIAS SA

  公开号：WO2014207113A1

  公开（公告）日：2014-12-31

  The present invention relates to modified eukaryotic microbial cells that have been engineered for producing fermentation products such as fatty acids, 1 -alcohols, β- keto-acids and -alcohols, β-hydroxyacids, 1,3-diols, trans-A2-fatty acids, alkenes, alkanes and derivatives thereof. To this end the eukaryotic microbial cells have been modified to express enzymes of the fatty acid β-oxidation cycle in the cytosol of the cell, in the absence of fatty acids and in the presence of a non-fatty acid carbon source. The cells are further modified to express a metabolic route for producing under oxic conditions, acetyl-CoA from the non-fatty acid carbon source to feed into and drive the β-oxidation cycle in the biosynthetic direction and, to express termination enzymes for conversion of reaction β-oxidation cycle intermediates into the desired fermentation product. The invention further relates to oxic processes wherein the cells are used to produce the fermentation products.