(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2,6-diaminohexanoic acid | 31325-38-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2,6-diaminohexanoic acid
• CAS: 31325-38-9
• 化学式: C15H25N3O5
• 分子量: 327.38
• InChiKey: HFLSGZWXECPQND-JUUVMNCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.13
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  173
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
  申请人：Collins A. Douglas

  公开号：US20060074034A1

  公开（公告）日：2006-04-06

  This invention is in the area of cobalamin-mediated delivery of nucleic acids and analogs and derivatives thereof to a host to affect gene expression.

  这项发明涉及钴胺素介导的核酸及其类似物和衍生物的传递到宿主以影响基因表达。
• [EN] TOPOSIOMERASE INHIBITORS<br/>[FR] INHIBITEURS DE TOPOISOMÉRASE
  申请人：UNIV RUTGERS

  公开号：WO2010127363A1

  公开（公告）日：2010-11-04

  The invention provides compounds of formula I: (I) wherein A, B, W, Y, Z, R1 R3 and R4 have any of the meanings defined in the specification and their salts as well as additional compounds and their salts. The invention also provides pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer, a bacterial infection or a fungal infection using compounds of the invention.

  该发明提供了以下公式I的化合物：(I)，其中A、B、W、Y、Z、R1、R3和R4具有规范中定义的任意含义及其盐，以及其他化合物及其盐。该发明还提供了包含该发明化合物的药物组合物，制备该发明化合物的方法，用于制备该发明化合物的有用中间体，以及使用该发明化合物治疗癌症、细菌感染或真菌感染的治疗方法。
• Molecular targeting agents
  申请人：Schultz Michael K.

  公开号：US20100234450A1

  公开（公告）日：2010-09-16

  The present invention relates to aptamer conjugates comprising a metal chelating group and to methods of using these aptamers.

  本发明涉及具有金属螯合基团的适配体共轭物，并涉及使用这些适配体的方法。
• AZA-peptide protease inhibitors
  申请人：Cannizzaro Carina E.

  公开号：US20090099096A1

  公开（公告）日：2009-04-16

  The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

  本发明涉及以下化合物（I）或其药学上可接受的盐、溶剂、酯和/或膦酸酯，含有这些化合物的组合物，以及包括给予这些化合物的治疗方法。
• Epoxy-containing poly(ester amides) and method of use
  申请人：Katsarava Ramaz

  公开号：US20080050419A1

  公开（公告）日：2008-02-28

  The invention provides aliphatic epoxy-containing PEA polymer compositions with film-forming properties. The aliphatic epoxy di-acids used in the invention PEA compositions include non-toxic fatty aliphatic epoxy homologs. A second, C-protected L-lysine-based monomer can be introduced into the polymer to provide additional chain flexibility. The invention PEA polymer compositions are useful for delivery of bioactive agents when administered internally or used in the manufacture of implantable medical devices. Biodegradable hydrogels can be made using the invention epoxy-containing PEAs.

  该发明提供了具有成膜性能的脂肪族环氧含有PEA聚合物组成物。该发明中使用的脂肪族环氧二酸包括非毒性脂肪族环氧同系物。第二种基于C-保护的L-赖氨酸单体可以引入到聚合物中以提供额外的链柔性。该发明的PEA聚合物组成物在内部给药时或用于制造可植入医疗器械时，可用于传递生物活性剂。使用该发明的环氧含有PEAs可以制造可生物降解的水凝胶。