4-Amino-1-guanylpiperidine-4-carboxylic acid | 31364-50-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Amino-1-guanylpiperidine-4-carboxylic acid
• 英文别名: 4-amino-1-carbamimidoylpiperidine-4-carboxylic acid
• CAS: 31364-50-8
• 化学式: C₇H₁₄N₄O₂
• 分子量: 186.21
• InChiKey: AWLMDHXPKGLEQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• THERAPEUTIC PEPTIDES
  申请人：Strom Morten

  公开号：US20130035296A1

  公开（公告）日：2013-02-07

  The present invention provides a peptide, peptidomimetic or amino acid derivative having a net positive charge of at least +2 and incorporating a disubstituted β amino acid, each of the substituting groups in the β amino acid, which may be the same or different, comprises at least (7) non-hydrogen atoms, is lipophilic and has at least one cyclic group, one or more cyclic groups within a substituting group may be linked or fused to one or more cyclic groups within the other substituting group and where cyclic groups are fused in this way the combined total number of non-hydrogen atoms for the two substituting groups is at least (12), for use as a cytolytic therapeutic agent; as well as non therapeutic uses of these molecules and certain defined novel compounds from within this definition.

  本发明提供了一种具有至少+2的净正电荷并且包含二取代β氨基酸的肽、肽类似物或氨基酸衍生物，β氨基酸中的每个取代基（可能相同也可能不同）包括至少（7）个非氢原子，具有亲脂性并且至少有一个环状基团，一个或多个取代基内的环状基团可以连接或融合到另一个取代基内的一个或多个环状基团中，当环状基团以这种方式融合时，两个取代基的非氢原子的总数至少为（12），用作溶细胞治疗剂；以及这些分子的非治疗用途以及从该定义中确定的某些新化合物。
• ANTIMICROBIAL COMPOUNDS
  申请人：Stensen Wenche

  公开号：US20110301076A1

  公开（公告）日：2011-12-08

  The present invention relates to a compound of formula (I) AA-AA-AA-R 1 —R 2 (I) wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27 non-hydrogen atoms; R 1 is a N atom, which may be substituted by a branched or unbranched C 1 -C 10 alkyl or aryl group, which group may incorporate up to 2 heteroatoms selected from N, O and S; and R 2 is an aliphatic moiety having 2-20 non-hydrogen atoms, said moiety being linear, branched or cyclic. The invention further relates to formulations containing these compounds, solid supports having these compounds attached thereto, the use of these compounds in therapy, particularly as antimicrobial, anti-tumour or anti-biofilm agents and non-therapeutic uses of these compounds, particularly their use in inhibiting biofilm formation or removing a biofilm.

  本发明涉及一种具有以下结构的化合物(I) AA-AA-AA-R1—R2(I)，其中，任意顺序中，所述的2个AA（氨基酸）基团是带正电的氨基酸，而1个AA是带有亲脂性R基团的氨基酸，所述R基团具有14-27个非氢原子；R1是一个N原子，可以被支链或非支链的C1-C10烷基或芳基取代，该基团最多可以包含2个从N、O和S中选择的杂原子；R2是具有2-20个非氢原子的脂肪族基团，该基团是直链、支链或环状的。该发明还涉及含有这些化合物的配方、固体支持物上附着这些化合物、这些化合物在治疗中的使用，特别是作为抗微生物、抗肿瘤或抗生物膜剂，以及这些化合物的非治疗用途，特别是它们在抑制生物膜形成或去除生物膜中的应用。
• [EN] ANTIMICROBIAL FORMULATIONS COMPRISING SILICONE<br/>[FR] FORMULATIONS ANTIMICROBIENNES COMPRENANT DU SILICONE
  申请人：AMICOAT AS

  公开号：WO2021250286A1

  公开（公告）日：2021-12-16

  The present invention provides a controlled release formulation comprising a silicone substrate which comprises a compound of Formula (I): AA-AA-AA-X-Y. The invention further provides methods of making these formulations, medical devices such as dressings incorporating said formulations and medical uses thereof.

  本发明提供了一种控制释放的配方，包括一个硅基底物，该底物包括式(I)的化合物：AA-AA-AA-X-Y。本发明还提供了制备这些配方的方法，包括将该配方用于制作敷料的医疗器械和医疗用途。
• TREATMENT OF BIOFILMS
  申请人：Stensen Wenche

  公开号：US20110236453A1

  公开（公告）日：2011-09-29

  The present invention relates to a peptide or peptidomimetic for use in the treatment of a biofilm-associated infection in a subject, wherein said peptide or peptidomimetic a) carries a net positive charge, b) is 1 to 6 amino acids in length or is an equivalently sized peptidomimetic; and c) is amphipathic in nature, having one or more lipophilic groups, one of said lipophilic groups comprising at least 7 non-hydrogen atoms.

  本发明涉及用于治疗生物膜相关感染的肽或类肽，其中所述肽或类肽a）具有净正电荷，b）长度为1至6个氨基酸或等效大小的类肽；c）是两性的，具有一个或多个亲脂性基团，其中一个亲脂性基团含有至少7个非氢原子。
• [EN] MEDICAL DEVICES AND MATERIALS COMPRISING BIODEGRADABLE POLYESTERS<br/>[FR] DISPOSITIFS MÉDICAUX ET MATÉRIAUX COMPRENANT DES POLYESTERS BIODÉGRADABLES
  申请人：AMICOAT AS

  公开号：WO2021250283A1

  公开（公告）日：2021-12-16

  The present invention provides a formulation comprising a biodegradable polyester compounded with a compound of Formula (I): AA-AA-AA-X-Y. The invention further provides methods of making these formulations, medical devices such as sutures comprising said formulations and methods of making said devices.

  本发明提供了一种配方，包括一种可生物降解的聚酯和一种化合物（I）的混合物：AA-AA-AA-X-Y。本发明还提供了制备这些配方的方法，包括含有该配方的医疗器械，如缝合线，以及制造该器械的方法。