Acetyl-arginyl-glycyl-aspartyl-serinamide | 122207-62-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetyl-arginyl-glycyl-aspartyl-serinamide
• 英文别名: (3S)-3-[[2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
• CAS: 122207-62-9
• 化学式: C₁₇H₃₀N₈O₈
• 分子量: 474.5
• InChiKey: GFOJSWCCTWFSJD-DCAQKATOSA-N

物化性质

• 密度：
  1.59±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.4
• 重原子数：
  33
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  281
• 氢给体数：
  9
• 氢受体数：
  9

文献信息

• Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
  申请人：Omeros Corporation

  公开号：US20030195461A1

  公开（公告）日：2003-10-16

  A method and solution for perioperatively inhibiting tumor cell adhesion and a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one anti-tumor cell adhesion agent and multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit tumor cell adhesion, pain and inflammation includes at least one anti-tumor cell adhesion agent, a serotonin 2 antagonist, a serotonin 3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin 1 antagonist, a neurokinin 2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin 1 antagonist, a bradykinin 2 antagonist and a &mgr;-opioid agonist.

  一种围手术期抑制肿瘤细胞粘附和一般外科手术（包括口腔/牙科手术）伤口处各种疼痛和炎症过程的方法和溶液。该溶液最好包括至少一种抗肿瘤细胞粘附剂和多种稀释浓度的疼痛和炎症抑制剂，以生理载体（如生理盐水或乳酸林格氏液）为载体。该溶液可在手术过程中通过持续冲洗伤口来预先抑制疼痛，同时避免口服、肌肉注射、皮下注射或静脉注射大剂量药剂所带来的不良副作用。一种优选的抑制肿瘤细胞粘附、疼痛和炎症的方案包括至少一种抗肿瘤细胞粘附剂、一种血清素 2 拮抗剂、5-羟色胺 3 拮抗剂、组胺拮抗剂、5-羟色胺激动剂、环氧化酶抑制剂、神经激肽 1 拮抗剂、神经激肽 2 拮抗剂、嘌呤受体拮抗剂、ATP 敏感钾通道开放剂、钙通道拮抗剂、缓激肽 1 拮抗剂、缓激肽 2 拮抗剂和阿片激动剂。
• IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION
  申请人：Omeros Corporation

  公开号：EP1567179A1

  公开（公告）日：2005-08-31
• EP1567179A4
  申请人：——

  公开号：EP1567179A4

  公开（公告）日：2007-06-27
• US6492332B1
  申请人：——

  公开号：US6492332B1

  公开（公告）日：2002-12-10
• [EN] IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION<br/>[FR] SOLUTION D'IRRIGATION ET METHODE D'INHIBITION DE L'ADHESION DE CELLULES TUMORALES, DE DOULEURS ET D'INFLAMMATIONS
  申请人：OMEROS CORP

  公开号：WO2004043479A1

  公开（公告）日：2004-05-27

  A method and solution for perioperatively inhibiting tumor cell adhesion and a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one anti-tumor cell adhesion agent and multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit tumor cell adhesion, pain and inflammation includes at least one anti-tumor cell adhesion agent, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokininl antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykininl antagonist, a bradykinin2 antagonist and a ν-opioid agonist.