Hydroxyethyl-l-glutamine | 27878-59-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Hydroxyethyl-l-glutamine
• 英文别名: (2S)-5-amino-2-(2-hydroxyethylamino)-5-oxopentanoic acid
• CAS: 27878-59-7
• 化学式: C₇H₁₄N₂O₄
• 分子量: 190.2
• InChiKey: FVXWJHWNSKJFAH-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Polyglutamic Acids Functionalised by Histidine Derivatives and Hydrophobic Groups and the Uses Thereof, in Particular for Therapeutic Purposes
  申请人：Soula Olivier

  公开号：US20100034886A1

  公开（公告）日：2010-02-11

  The invention relates to novel biodegradable materials based on modified polyamino acids and suitable, in particular, for vectoring active substance(s) (AS). Said invention also relates to novel pharmaceutical, cosmetic, dietary or plant protective compositions which are based on said polyamino acids. The aim of said invention is to provide a novel polymer raw material usable for vectoring the AS and capable to optimally meet all specification in this area: biocompatibility, biodegradability, ability to become easily associated with many active substances or to solubilise them and to release said active substances in vivo. The aim is attained to 30 carbon atoms. Said polyglutamates modified by histidine derivatives are soluble with pH lower than 5 and are easily and economically convertible into active substance vectorization particles which are able to form stable aqueous colloidal suspensions. On the contrary, said modified polyglutamates are insoluble in water with a physiological pH (7.4), and thereby have to be precipitated on an injection site in the case of a subcutaneous injection.

  该发明涉及基于改性聚氨基酸的新型可生物降解材料，特别适用于载荷活性物质（AS）。该发明还涉及基于这些聚氨基酸的新型药用、化妆品、膳食或植物保护组合物。 该发明的目的是提供一种新型聚合物原料，可用于载荷AS，并能够最佳地满足该领域的所有规范要求：生物相容性、生物降解性、能够轻松与许多活性物质结合或溶解它们，并在体内释放所述活性物质。该目的在30个碳原子处实现。 通过组氨酸衍生物改性的聚谷氨酸在pH低于5时可溶解，并且可以经济地转化为能够形成稳定水性胶体悬浮液的活性物质载体颗粒。相反，这些改性聚谷氨酸在生理pH值（7.4）下不溶于水，因此在皮下注射时必须在注射部位沉淀。
• COPOLYHYDROXYALKYLGLUTAMINES FUNCTIONALISED WITH HYDROPHOBIC GROUPS, AND USES THEREOF, ESPECIALLY IN THERAPEUTICS
  申请人：Soula Rémi

  公开号：US20110044930A1

  公开（公告）日：2011-02-24

  The invention relates to novel biodegradable materials which are based on modified polyamino acids and which can be used for the vectorisation of active principle(s) (AP). The invention also relates to novel pharmaceutical, cosmetic, dietary or phytosanitary compositions based on said polyamino acids. The aim of the invention is to provide a novel polymer raw material which can be used for the vectorisation of active principles and which can optimally fulfil all required specifications in said area, namely: biocompatibility, biodegradability and the ability to become easily associated with many active principles or to solubilise said principles and to release same in vivo. Said aim is achieved with novel copolyhydroxyalkylglutamines comprising glutamine units and optionally glutamate units and bearing hydrophobic groups containing between 8 and 30 carbon atoms. Said copolyhydroxyalkylglutamines are amphiphilic and can be easily and economically transformed into particles for the vectorisation of active principles, whereby said particles can form stable aqueous colloidal suspensions.

  该发明涉及基于改性聚氨基酸的新型可生物降解材料，可用于活性成分的载体化。该发明还涉及基于这些聚氨基酸的新型药用、化妆品、膳食或植物保护组合物。该发明的目的是提供一种新型聚合物原料，可用于活性成分的载体化，并能够最佳地满足该领域中所有所需规格，即生物相容性、生物降解性以及能够轻松与许多活性成分结合或溶解这些成分并在体内释放的能力。通过包含谷氨酰胺单元和可选的谷氨酸单元以及带有含有8至30个碳原子的疏水基团的新型共聚羟基烷基谷氨酰胺，实现了该目的。这些共聚羟基烷基谷氨酰胺是两性的，可以轻松且经济地转化为用于活性成分载体化的颗粒，这些颗粒可以形成稳定的水胶体悬浮液。
• ANTICANCER MICRORNA AND LIPID FORMULATIONS THEREOF
  申请人：INTERNA TECHNOLOGIES B.V.

  公开号：US20210038732A1

  公开（公告）日：2021-02-11

  The present invention relates to a lipid formulation comprising microRNA. The formulation comprises cationic lipids that can form lipid nanoparticles with the microRNA. The formulations are useful in medicine.

  本发明涉及一种含有微RNA的脂质配方。该配方包括能与微RNA形成脂质纳米粒子的阳离子脂质。这些配方在医学上很有用。
• SUGAR AND PEG FUNCTIONALIZED POLYACETALS WITH CONTROLLED PH-DEPENDENT DEGRADATION
  申请人：Peña Gulin Oscar

  公开号：US20140072513A1

  公开（公告）日：2014-03-13

  The present invention relates to degradable polyacetal polymers having a C(O)—(CH 2 CH 2 O) n —R 5 or a saccharide attached to amine radical of the backbone of the polymer, their polymer-active agent conjugates and their preparation processes, to compositions, and hydrogels containing them, as well as their use in therapy, diagnostic imaging and cosmetics.

  本发明涉及可降解的聚乙缩醛聚合物，其具有C(O)—(CH2CH2O)n—R5或糖苷连接到聚合物骨架的胺基上，它们的聚合物活性剂结合物以及它们的制备过程，还涉及含有它们的组合物和水凝胶，以及它们在治疗、诊断成像和化妆品中的应用。
• MULTI-VALENT ADJUVANT DISPLAY
  申请人：Psioxus Therapeutics Limited

  公开号：US20170112923A1

  公开（公告）日：2017-04-27

  The present invention provides an adjuvant-polymer construct comprising a polymer backbone which is covalently linked to 3 or more adjuvants, wherein the 3 or more adjuvants are each present in a pendant side chain, the adjuvants being connected to the polymer backbone either directly or via a spacer group.

  本发明提供了一种佐剂-聚合物构造体，包括一个聚合物骨架，该聚合物骨架与3个或更多佐剂共价连接，其中这3个或更多佐剂分别存在于一个挂链侧链中，佐剂与聚合物骨架之间通过直接连接或通过间隔基团连接。