5-茚满甲酰胺 | 103204-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 5-茚满甲酰胺
• 英文名称: Indan-carbonsaeure-(5)-amid
• 英文别名: indan-5-carboxamide；Indan-5-carbamid；2,3-dihydro-1H-indene-5-carboxamide
• CAS: 103204-17-7
• 化学式: C₁₀H₁₁NO
• mdl: MFCD10669580
• 分子量: 161.203
• InChiKey: GBPWDYCNVWWKRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-茚满甲酰胺 、 alkaline earth salt of/the/ methylsulfuric acid 生成 5-氨基茚旦
  参考文献：
  名称：

  Borsche; John, Chemische Berichte, 1924, vol. 57, p. 659

  摘要：

  DOI：
• 作为产物：
  描述：

  茚烷-5-羧酸 在 五氯化磷 、 氨 作用下， 生成 5-茚满甲酰胺
  参考文献：
  名称：

  v. Braun; Kirschbaum; Schuhmann, Chemische Berichte, 1920, vol. 53, p. 1165

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR<br/>[FR] INHIBITEURS DE PRÉSENTATION D'ANTIGÈNE PAR HLA-DR
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2021198283A1

  公开（公告）日：2021-10-07

  Chromanone compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the inhibition of antigen presentation by HLA-DR.

  Chromanone化合物，含有它们的药物组合物，制备它们的方法，以及使用它们的方法，包括用于治疗与HLA-DR抗原呈递抑制相关的疾病状态、疾病和症状的方法。
• [EN] AMIDE COMPOUNDS, COMPOSITIONS AND APPLICATIONS THEREOF<br/>[FR] COMPOSÉS AMIDES, COMPOSITIONS ET APPLICATIONS DE CEUX-CI
  申请人：ADVINUS THERAPEUTICS LTD

  公开号：WO2013042139A1

  公开（公告）日：2013-03-28

  The present disclosure relates to substituted amide compounds that are inhibitors of Fatty Acid Amide Hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Fatty Acid Amide Hydrolase (FAAH), such as pain including acute and post operative pain, chronic pain, cancer pain, cancer chemotherapy induced pain, neuropathic pain, nociceptive pain, inflammatory pain, back pain, pain due to disease of various origin such as: diabetic neuropathy, neurotropic viral disease including human immunodeficient virus (HIV), herpes zoster such as post herpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve injury, carpal tunnel syndrome, immunologic mechanisms like multiple sclerosis; sleep disorders, anxiety and depression disorders, inflammatory disorders, weight and eating disorders, Parkinson's disease, addiction, spasticity, hypertension or other disorders. The disclosure also relates to the process of preparation of the amide compounds. Formula (1). The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

  本公开涉及替代酰胺化合物，这些化合物是脂肪酸酰胺水解酶（FAAH）的抑制剂，包括它们的立体异构体、互变异构体、前药、多型体、溶剂合物、药用盐以及含有它们的药物组合物。这些化合物在治疗、预防、预防、管理或辅助治疗与脂肪酸酰胺水解酶（FAAH）抑制相关的所有医疗状况中非常有用，例如疼痛，包括急性和术后疼痛，慢性疼痛，癌症疼痛，癌症化疗引起的疼痛，神经痛，伤害性疼痛，炎症性疼痛，背部疼痛，疾病引起的疼痛，如糖尿病性神经病变，神经病毒性疾病，包括人类免疫缺陷病毒（HIV），带状疱疹，如带状疱疹后神经痛；多发性神经病，神经毒性，机械神经损伤，腕管综合症，类似多发性硬化的免疫机制；睡眠障碍，焦虑和抑郁症，炎症性疾病，体重和进食障碍，帕金森病，成瘾，痉挛，高血压或其他疾病。该公开还涉及酰胺化合物的制备过程。公式（1）。本公开还涉及制备这类化合物的方法，以及含有它们的药物组合物。
• Novel succinate compounds, compositions and methods of use and preparation
  申请人：——

  公开号：US20020115863A1

  公开（公告）日：2002-08-22

  Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

  揭示了一种新型羟羧酸化合物。这些羟羧酸酯抑制肽变形酶（PDF），这是一种存在于原核生物中的酶。这些羟羧酸酯可用作抗微生物和抗生素。该发明的化合物表现出对肽变形酶的选择性抑制，而不影响其他金属蛋白酶如基质金属蛋白酶（MMPs）。该文还揭示了这些化合物的合成方法和使用方法。
• [EN] 6-SULFONAMIDE QUINOLINE AND CHROMENE DERIVATIVE AS ANDROGEN RECEPTOR ANTAGONISTS<br/>[FR] DERIVES 6-SULFONAMIDE QUINOLEINIQUES ET CHROMENIQUES A TITRE D'ANTAGONISTES DES RECEPTEURS D'ANDROGENE
  申请人：WARNER LAMBERT CO

  公开号：WO2004083204A1

  公开（公告）日：2004-09-30

  The present invention is directed to 6-sulfonamide quinoline and chromene derivatives of the formula (I) with the definitions of M, R1, R2, A and B according to claim 1 and to their use as androgen antagonists.

  本发明涉及公式(I)的6-磺酰胺喹啉和色烯衍生物，其中M、R1、R2、A和B的定义如权利要求1所述，并将其用作雄激素拮抗剂。
• [EN] NOVEL SUCCINATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION<br/>[FR] NOUVEAUX COMPOSES A BASE DE SUCCINATE, COMPOSITIONS LES CONTENANT, ET PROCEDES D'UTILISATION ET DE PREPARATION DE CEUX-CI
  申请人：VERSICOR INC

  公开号：WO2001044179A1

  公开（公告）日：2001-06-21

  Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

  本发明揭示了式（I）的新型羟肟酸化合物。这些羟肟酸盐抑制肽变形酶（PDF），一种存在于原核生物中的酶。这些羟肟酸盐可用作抗微生物和抗生素。本发明的化合物显示出对肽酰变形酶的选择性抑制，而不是其他金属蛋白酶如基质金属蛋白酶（MMPs）。本发明还揭示了这些化合物的合成和使用方法。