8-(2,3,4-Trimethoxy-phenyl)-5,8-dihydro-3H,4H-difuro[3,4-b;3',4'-e]pyridine-1,7-dione | 120292-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 8-(2,3,4-Trimethoxy-phenyl)-5,8-dihydro-3H,4H-difuro[3,4-b;3',4'-e]pyridine-1,7-dione
• 英文别名: 1H,3H-Difuro(3,4-b:3',4'-e)pyridine-1,7(4H)-dione, 5,8-dihydro-8-(2,3,4-trimethoxyphenyl)-；8-(2,3,4-trimethoxyphenyl)-5,11-dioxa-2-azatricyclo[7.3.0.03,7]dodeca-1(9),3(7)-diene-6,10-dione
• CAS: 120292-11-7
• 化学式: C₁₈H₁₇NO₇
• 分子量: 359.335
• InChiKey: WAMLVWKPFOLSDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,6-Dimethyl-4-(2,3,4-trimethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 氯仿 为溶剂， 以18%的产率得到8-(2,3,4-Trimethoxy-phenyl)-5,8-dihydro-3H,4H-difuro[3,4-b;3',4'-e]pyridine-1,7-dione
  参考文献：
  名称：

  Synthesis and pharmacological activity of difuro-1,4-dihydropyridines

  摘要：

  DOI：

  10.1007/bf00764462

文献信息

• SKRASTINSH, I. P.;KASTRON, V. V.;VITOLIN, R. O.;STIVRINYA, M. I.;ZOLOTOYA+, XIM.-FARMATS. ZH., 23,(1989) N, S. 176-178
  作者：SKRASTINSH, I. P.、KASTRON, V. V.、VITOLIN, R. O.、STIVRINYA, M. I.、ZOLOTOYA+

  DOI：——

  日期：——
• DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE
  申请人：ABBOTT LABORATORIES

  公开号：EP1131322A2

  公开（公告）日：2001-09-12
• [EN] DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSES DE DIHYDROPYRIDINE ET LEUR MODE D'UTILISATION
  申请人：ABBOTT LAB

  公开号：WO2000024741A2

  公开（公告）日：2000-05-04

  Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
• [EN] DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSES DE DIHYDROPYRIDINE ET PROCEDES D'UTILISATION
  申请人：ABBOTT LAB

  公开号：WO2001083480A2

  公开（公告）日：2001-11-08

  Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
• Synthesis and pharmacological activity of difuro-1,4-dihydropyridines
  作者：I. P. Skrastin'sh、V. V. Kastron、R. O. Vitolin'、M. I. Stivrinya、R. M. Zolotoyabko、G. Ya. Dubur

  DOI：10.1007/bf00764462

  日期：1989.2