4a,5,6,7,8,8a-hexahydro-2,3-di(pyridin-2-yl)quinoxaline | 1227254-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4a,5,6,7,8,8a-hexahydro-2,3-di(pyridin-2-yl)quinoxaline
• 英文别名: 2,3-Dipyridin-2-yl-4a,5,6,7,8,8a-hexahydroquinoxaline
• CAS: 1227254-60-5
• 化学式: C₁₈H₁₈N₄
• 分子量: 290.368
• InChiKey: PQJXKXGRRIZRSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二(2-吡啶基)乙二酮 、 1,2-二氨基环己烷 在 PEG-400 作用下， 反应 0.25h， 以90%的产率得到4a,5,6,7,8,8a-hexahydro-2,3-di(pyridin-2-yl)quinoxaline
  参考文献：
  名称：

  Synthesis of quinoxaline derivatives catalyzed by PEG-400

  摘要：

  Polyethylene glycol (PEG) was found to be an effective catalyst for the condensation of 1,2-diamines with 1,2-dicarbonyl compounds to afford the corresponding quinoxaline derivatives in excellent yields under mild reaction conditions. (C) 2009 Jin Xian Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2009.12.015

文献信息

• Synthesis of quinoxaline derivatives catalyzed by PEG-400
  作者：Xia Zhong Zhang、Jin Xian Wang、Yong Jun Sun、Hong Wen Zhan

  DOI：10.1016/j.cclet.2009.12.015

  日期：2010.4

  Polyethylene glycol (PEG) was found to be an effective catalyst for the condensation of 1,2-diamines with 1,2-dicarbonyl compounds to afford the corresponding quinoxaline derivatives in excellent yields under mild reaction conditions. (C) 2009 Jin Xian Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
• Microwave-Assisted Synthesis of Quinoxalines in PEG-400
  作者：Xia-Zhong Zhang、Jin-Xian Wang、Lin Bai

  DOI：10.1080/00397911.2010.496134

  日期：2011.7.15

  [image omitted] A rapid and efficient procedure for the synthesis of quinoxaline derivatives has been achieved by condensation of aryl-1,2-diamines with 1,2-dicarbonyl compounds catalyzed by polyethylene glycol under CEM-focused microwave-irradiation conditions.