methyl 3-{[(furan-2-yl)methylidene](oxido)amino}propanoate | 381167-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: methyl 3-{[(furan-2-yl)methylidene](oxido)amino}propanoate
• 英文别名: 1-(furan-2-yl)-N-(3-methoxy-3-oxopropyl)methanimine oxide
• CAS: 381167-04-0
• 化学式: C₉H₁₁NO₄
• 分子量: 197.191
• InChiKey: AXRCCFVGTZVEER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  糠醛肟 、 丙烯酸甲酯（MA） 在 三氟化硼丁醚络合物 、 cadmium(II) iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以88%的产率得到methyl 3-{[(furan-2-yl)methylidene](oxido)amino}propanoate
  参考文献：
  名称：

  Synthesis of alkyl nitrones by reaction of aldehyde and ketone oximes with α,β-unstaturated esters in the presence of Lewis acid

  摘要：

  Reactions of pyridinecarbaldehyde oximes, methyl pyridyl ketone oximes, furfural oxime, cinnamaldehyde oxime, and crotonaldehyde oxime with acrylic and methacrylic acid esters in the presence of a Lewis acid catalyst at room temperature followed the conjugate addition pattern to give the corresponding alkyl nitrones in good yield. The best yields were obtained using a 1: 1 mixture of CdI(2) and BF(3) center dot Bu(2)O as catalyst.

  DOI：

  10.1134/s1070428009040204

文献信息

• Synthesis of alkyl nitrones by reaction of aldehyde and ketone oximes with α,β-unstaturated esters in the presence of Lewis acid
  作者：A. Koçak、S. Malkondu、S. Kurbanli

  DOI：10.1134/s1070428009040204

  日期：2009.4

  Reactions of pyridinecarbaldehyde oximes, methyl pyridyl ketone oximes, furfural oxime, cinnamaldehyde oxime, and crotonaldehyde oxime with acrylic and methacrylic acid esters in the presence of a Lewis acid catalyst at room temperature followed the conjugate addition pattern to give the corresponding alkyl nitrones in good yield. The best yields were obtained using a 1: 1 mixture of CdI(2) and BF(3) center dot Bu(2)O as catalyst.