(S)-1-(4-methoxyphenyl)-3-[2-((E)-2-phenylethenyl)phenyl]butan-1-one | 1374988-85-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (S)-1-(4-methoxyphenyl)-3-[2-((E)-2-phenylethenyl)phenyl]butan-1-one
• 英文别名: (3S)-1-(4-methoxyphenyl)-3-[2-[(E)-2-phenylethenyl]phenyl]butan-1-one
• CAS: 1374988-85-8
• 化学式: C₂₅H₂₄O₂
• 分子量: 356.464
• InChiKey: OOLVRNSBUMTEGN-HYSAVQALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-(1,2-diphenylvinyl)boronic acid 、 1-(4-甲氧基-苯基)-丁-2-烯-1-酮 在 C₅₀H₆₈Cl₂O₄Rh₂ 、 caesium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 4.0h， 以95%的产率得到(S)-1-(4-methoxyphenyl)-3-[2-((E)-2-phenylethenyl)phenyl]butan-1-one
  参考文献：
  名称：

  Asymmetric conjugate addition of cis-2-arylethenylboronic acids catalyzed by chiral diene/rhodium complexes: 1,4-rhodium shift from alkenylrhodium to arylrhodium intermediates

  摘要：

  The reaction of (E)-1,2-diphenylethenylboronic acid 1 with 2-cyclohexenone in the presence of a chiral diene/rhodium catalyst (5 mol %) gave 3-[2-((E)-2-phenylethenyl)phenyl]cyclohexanone in 99% yield with 98.7% ee; the catalytic cycle involves a 1,4-rhodium shift from a 2-phenylethenylrhodium to an ortho-alkenylphenylrhodium intermediate. In the reaction of 1 with (E)-1-phenyl-2-buten-1-one, either the tandem 1,4-shift/arylation product or the direct alkenylation product is formed selectively by an appropriate choice of chiral diene ligand. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.03.004

文献信息

• Asymmetric conjugate addition of cis-2-arylethenylboronic acids catalyzed by chiral diene/rhodium complexes: 1,4-rhodium shift from alkenylrhodium to arylrhodium intermediates
  作者：Keigo Sasaki、Tamio Hayashi

  DOI：10.1016/j.tetasy.2012.03.004

  日期：2012.3

  The reaction of (E)-1,2-diphenylethenylboronic acid 1 with 2-cyclohexenone in the presence of a chiral diene/rhodium catalyst (5 mol %) gave 3-[2-((E)-2-phenylethenyl)phenyl]cyclohexanone in 99% yield with 98.7% ee; the catalytic cycle involves a 1,4-rhodium shift from a 2-phenylethenylrhodium to an ortho-alkenylphenylrhodium intermediate. In the reaction of 1 with (E)-1-phenyl-2-buten-1-one, either the tandem 1,4-shift/arylation product or the direct alkenylation product is formed selectively by an appropriate choice of chiral diene ligand. (C) 2012 Elsevier Ltd. All rights reserved.