(N',N''E,N',N''E)-N',N''-(2,2'-(3-(tert-butyldimethylsilyloxy)propylazanediyl)bis(1-(2-bromophenyl)ethan-2-yl-1-ylidene))bis(4-methylbenzenesulfonohydrazide) | 1258383-59-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (N',N''E,N',N''E)-N',N''-(2,2'-(3-(tert-butyldimethylsilyloxy)propylazanediyl)bis(1-(2-bromophenyl)ethan-2-yl-1-ylidene))bis(4-methylbenzenesulfonohydrazide)
• 英文别名: N-[(E)-[1-(2-bromophenyl)-2-[[(2E)-2-(2-bromophenyl)-2-[(4-methylphenyl)sulfonylhydrazinylidene]ethyl]-[3-[tert-butyl(dimethyl)silyl]oxypropyl]amino]ethylidene]amino]-4-methylbenzenesulfonamide
• CAS: 1258383-59-3
• 化学式: C₃₉H₄₉Br₂N₅O₅S₂Si
• 分子量: 919.874
• InChiKey: BYFUEYYXZAFEQA-HDNVMLHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.61
• 重原子数：
  54
• 可旋转键数：
  18
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (N',N''E,N',N''E)-N',N''-(2,2'-(3-(tert-butyldimethylsilyloxy)propylazanediyl)bis(1-(2-bromophenyl)ethan-2-yl-1-ylidene))bis(4-methylbenzenesulfonohydrazide) 在 sodium carbonate 、 copper(l) iodide 、 N,N'-二甲基乙二胺 作用下， 以 乙醇 、 水 为溶剂， 反应 0.2h， 以95%的产率得到3-(tert-butyldimethylsilyloxy)-N,N-bis((1-tosyl-1H-indazol-3-yl)methyl)propan-1-amine
  参考文献：
  名称：

  A novel and efficient synthesis of 3-aminomethyl-N-tosyl-indazoles

  摘要：

  A practical and environmentally friendly synthesis of 3-aminomethyl-N-tosyl-indazoles is developed. The in situ formed vinyl azines are reacted with amines to furnish amino functionalized anti-hydrazones in excellent yields. Subsequent copper-catalyzed cyclization at ambient temperature is effective and desired compounds are obtained in short reaction times. Also, the formation of bisindazoles is presented for the first time. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.069
• 作为产物：
  描述：

  N-[[2-bromo-1-(2-bromophenyl)ethylidene]amino]-4-methylbenzenesulfonamide 、 3-(叔丁基二甲基甲硅烷基氧基)丙胺 以 水 、 乙腈 为溶剂， 反应 0.5h， 以81%的产率得到(N',N''E,N',N''E)-N',N''-(2,2'-(3-(tert-butyldimethylsilyloxy)propylazanediyl)bis(1-(2-bromophenyl)ethan-2-yl-1-ylidene))bis(4-methylbenzenesulfonohydrazide)
  参考文献：
  名称：

  A novel and efficient synthesis of 3-aminomethyl-N-tosyl-indazoles

  摘要：

  A practical and environmentally friendly synthesis of 3-aminomethyl-N-tosyl-indazoles is developed. The in situ formed vinyl azines are reacted with amines to furnish amino functionalized anti-hydrazones in excellent yields. Subsequent copper-catalyzed cyclization at ambient temperature is effective and desired compounds are obtained in short reaction times. Also, the formation of bisindazoles is presented for the first time. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.069

文献信息

• A novel and efficient synthesis of 3-aminomethyl-N-tosyl-indazoles
  作者：Tuula Kylmälä、Antti Hämäläinen、Noora Kuuloja、Jan Tois、Robert Franzén

  DOI：10.1016/j.tet.2010.09.069

  日期：2010.11

  A practical and environmentally friendly synthesis of 3-aminomethyl-N-tosyl-indazoles is developed. The in situ formed vinyl azines are reacted with amines to furnish amino functionalized anti-hydrazones in excellent yields. Subsequent copper-catalyzed cyclization at ambient temperature is effective and desired compounds are obtained in short reaction times. Also, the formation of bisindazoles is presented for the first time. (C) 2010 Elsevier Ltd. All rights reserved.