N-Acetyl-prolin-methylamid | 24847-46-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-prolin-methylamid
• 英文别名: Ac-ProNHMe；N-acetylproline N-methylamide；1-acetyl-N-methylpyrrolidine-2-carboxamide
• CAS: 24847-46-9
• 化学式: C₈H₁₄N₂O₂
• mdl: MFCD18816718
• 分子量: 170.211
• InChiKey: DPDXFAYSYVRXMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲胺 、 alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 作用下， 生成 N-Acetyl-prolin-methylamid
  参考文献：
  名称：

  Near Infrared Spectra of Compounds with Two Peptide Bonds and the Configuration of a Polypeptide Chain. II

  摘要：

  DOI：

  10.1021/ja01138a058

文献信息

• SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING NITROGEN-CONTAINING ALICYCLIC SKELETON
  申请人：Ohgi Tadaaki

  公开号：US20120035246A1

  公开（公告）日：2012-02-09

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供了一种新型的核酸分子，可以轻松高效地制备，并能抑制基因表达。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子包括：一个区域（X）；一个连接区域（Lx）；和一个区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。至少其中一个区域（X）和（Xc）包含表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和一个哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• HETERO RING DERIVATIVE
  申请人：Takahashi Fumie

  公开号：US20120165309A1

  公开（公告）日：2012-06-28

  [Object] A novel and excellent method for preventing or treating rejection in the transplantation of various organs, allergy diseases, autoimmune diseases, hematologic tumor, or the like, based on a PI3Kδ-selective inhibitory action and/or an IL-2 production inhibitory action, and/or a B cell proliferation inhibitory action (including an activation inhibitory action), is provided [Means for Solution] It was found that a 3-substituted triazine or 3-substituted pyrimidine derivative exhibits a PI3Kδ-selective inhibitory action, and/or an IL-2 production inhibitory action, and/or a B cell proliferation inhibitory action (including an activation inhibitory action), and can be an agent for preventing or treating rejection in the transplantation of various organs, allergy diseases (asthma, atopic dermatitis, etc.), autoimmune diseases (rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, etc.), hematologic tumor (leukemia etc.), or the like, thereby completing the present invention.

  [目标]提供一种基于PI3Kδ选择性抑制作用和/或IL-2产生抑制作用和/或B细胞增殖抑制作用（包括激活抑制作用）的新颖优良方法，用于预防或治疗各种器官移植、过敏性疾病、自身免疫性疾病、血液肿瘤等的排斥反应。 [解决方案]发现3-取代-1,3,5-三嗪或3-取代嘧啶衍生物表现出PI3Kδ选择性抑制作用和/或IL-2产生抑制作用和/或B细胞增殖抑制作用（包括激活抑制作用），可以作为预防或治疗各种器官移植、过敏性疾病（哮喘、特应性皮炎等）、自身免疫性疾病（类风湿性关节炎、银屑病、溃疡性结肠炎、克罗恩病、系统性红斑狼疮等）、血液肿瘤（白血病等）等排斥反应的药物，从而完成了本发明。
• Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic Acid and Derivatives Thereof, Process for their Production and Use for the Production of Pharmaceutical Agents
  申请人：LEHMANN Lutz

  公开号：US20120064002A1

  公开（公告）日：2012-03-15

  Enantiomer-pure compounds of general formulas VIIa and VIIb in which A stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.

  本文描述了通式VIIa和VIIb的对映体纯化合物，其中A代表一个羧基（—COO—），Z和R具有不同的含义，以及它们的使用。
• Single-Stranded Nucleic Acid Molecule Having Nitrogen-Containing Alicyclic Skeleton
  申请人：BONAC CORPORATION

  公开号：US20140171633A1

  公开（公告）日：2014-06-19

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供一种新型核酸分子，可以轻松高效地制备，并且可以抑制基因表达。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子包括：区域（X）；连接区域（Lx）；和区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。区域（X）和（Xc）中至少有一个包含表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• Single-Stranded Nucleic Acid Molecule for Controlling Gene Expression
  申请人：BONAC CORPORATION

  公开号：US20150011605A1

  公开（公告）日：2015-01-08

  Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5′ side to the 3′ side: a 5′ side region (Xc); an inner region (Z); and a 3′ side region (Yc). The inner region (Z) is composed of an inner 5′ side region (X) and an inner 3′ side region (Y) that are linked to each other. The 5′ side region (Xc) is complementary to the inner 5′ side region (X). The 3′ side region (Yc) is complementary to the inner 3′ side region (Y). At least one of the inner region (Z), the 5′ side region (Xc), and the 3′ side region (Yc) includes the expression inhibitory sequence.

  提供的是一种新型核酸分子，它是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子从5'端到3'端的序列包括：一个5'端区域（Xc）；一个内部区域（Z）；以及一个3'端区域（Yc）。内部区域（Z）由内部5'端区域（X）和内部3'端区域（Y）组成，它们彼此连接。5'端区域（Xc）与内部5'端区域（X）互补。3'端区域（Yc）与内部3'端区域（Y）互补。内部区域（Z）、5'端区域（Xc）和3'端区域（Yc）中至少有一个包含表达抑制序列。