N-(β-DL-Aspartyl)-ethylamin | 63341-43-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(β-DL-Aspartyl)-ethylamin
• 英文别名: N⁴-ethyl-dl-asparagine；N⁴-Aethyl-DL-asparagin；dl-Asparaginsaeure-β-mono-aethylamid；2-Amino-4-(ethylamino)-4-oxobutanoic acid
• CAS: 63341-43-5
• 化学式: C₆H₁₂N₂O₃
• 分子量: 160.173
• InChiKey: UIRMLADHOCKNIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 N-(β-DL-Aspartyl)-ethylamin
  参考文献：
  名称：

  Syntheses of Aspartic Acid Derivatives. II. N-Alkylated α- and β-Asparagines

  摘要：

  DOI：

  10.1021/ja01594a034

文献信息

• [EN] ANTIFUNGAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIFONGIQUES
  申请人：UNIV LEUVEN KATH

  公开号：WO2011072345A1

  公开（公告）日：2011-06-23

  The present invention relates to a series of novel compounds which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparation, pharmaceutical compositions comprising them and to the compounds for use as a medicament, more in particular antifungal medicament.

  本发明涉及一系列已被证明具有抗真菌活性的新化合物。因此，该发明涉及新化合物、其制备方法、包含它们的药物组合物以及用作药物，尤其是抗真菌药物的化合物。
• SUBSTITUTED AMINE DERIVATIVE AND MEDICINAL COMPOSITION COMPRISING SAME AS THE ACTIVE INGREDIENT
  申请人：Kotobuki Pharmaceutical Co., Ltd.

  公开号：EP2332953A1

  公开（公告）日：2011-06-15

  A compound represented by following general formula (I) : wherein, ---- represents a single bond or a double bond; L represents -NH- or the like; X1 represents N or C, provided that in the case where X1 is N, X2 represents C-R and in the case where X1 is C, X2 represents N-R1 or the like; Y's may be either the same or different and represent CH2 or the like; A represents a non-natural sugar residue represented by following general formula: wherein, m represents 0 to 1; ---- represents a single bond or a double bond; X represents O or the like; R3 to R8 may be either the same or different and represent hydroxy group or the like; and B represents a group represented by following general formula: wherein, n and k represent 0 to 5; ---- represents a single bond or a double bond; Z1 to Z16 may be either the same or different and represent CH or the like; R10 and R11 may be either the same or different and represent a lower alkoxy group having 1 to 5 carbon atoms or the like; and R15 represents a hydrogen atom or the like, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or solvate thereof. Because of having an excellent CNT2 inhibitory activity and showing a high in vivo stability and stable physicochemical properties, the aforesaid compound is useful as a remedy for hyperuricemia.

  以下是通式（I）所代表的化合物： 其中，----代表单键或双键；L代表-NH-或类似结构；X1代表N或C，若X1为N，则X2代表C-R，若X1为C，则X2代表N-R1或类似结构；Y可以相同也可以不同，代表CH2或类似结构；A代表以下通式所代表的非天然糖残基： 其中，m代表0到1；----代表单键或双键；X代表O或类似结构；R3至R8可以相同也可以不同，代表羟基或类似结构；B代表以下通式所代表的基团： 其中，n和k代表0到5；----代表单键或双键；Z1至Z16可以相同也可以不同，代表CH或类似结构；R10和R11可以相同也可以不同，代表具有1到5个碳原子的低碳基氧基或类似结构；R15代表氢原子或类似结构，其药学上可接受的盐、前药、水合物或溶剂化物。由于具有优异的CNT2抑制活性，并且表现出高度的体内稳定性和稳定的物理化学性质，因此上述化合物可用作治疗高尿酸血症的药物。
• Oxysterol-therapeutic agent derivative for bone healing
  申请人：Warsaw Orthopedic, Inc.

  公开号：US10294264B2

  公开（公告）日：2019-05-21

  Oxysterol-therapeutic agent derivatives or OXY133-therapeutic agent derivative compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction and/or osteoconduction. Methods of synthesizing in a single container OXY133-therapeutic agent derivatives having high yields and improved process safety are also provided. Methods for synthesizing OXY133-therapeutic agent derivatives that are stereoselective are also provided.

  提供了用于促进成骨、骨诱导和/或骨诱导的氧基甾醇治疗剂衍生物或 OXY133 治疗剂衍生物化合物及其合成方法。还提供了在单个容器中合成 OXY133-治疗剂衍生物的方法，该方法产量高，工艺安全性更高。还提供了具有立体选择性的 OXY133 治疗剂衍生物的合成方法。
• Piutti, Gazzetta Chimica Italiana, 1888, vol. 18, p. 471,478
  作者：Piutti

  DOI：——

  日期：——
• ALKYLAMINES AND THEIR PRECURSORS AS SPECIFIC MODULATORS OF HUMAN GAMMA-DELTA T CELL FUNCTION
  申请人：THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

  公开号：EP1090106A2

  公开（公告）日：2001-04-11