4-amino-6-(4-methoxyphenyl)-2,3-dimethylthieno[2,3-b]pyridine | 1251920-90-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-amino-6-(4-methoxyphenyl)-2,3-dimethylthieno[2,3-b]pyridine
• 英文别名: 6-(4-Methoxyphenyl)-2,3-dimethylthieno[2,3-b]pyridin-4-amine；6-(4-methoxyphenyl)-2,3-dimethylthieno[2,3-b]pyridin-4-amine
• CAS: 1251920-90-7
• 化学式: C₁₆H₁₆N₂OS
• 分子量: 284.382
• InChiKey: SSBQMXVWIXVXFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  76.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-3-腈基-4,5-二甲基噻吩 、 对甲氧基苯乙酮 在 silica gel 、 ytterbium(III) triflate 作用下， 反应 0.08h， 以92%的产率得到4-amino-6-(4-methoxyphenyl)-2,3-dimethylthieno[2,3-b]pyridine
  参考文献：
  名称：

  Microwave-assisted novel synthesis of amino-thieno[3,2-b]pyridines under solvent-free conditions

  摘要：

  In the presence of a catalytic amount of ytterbium(III) triflate and under microwave irradiation, mixtures of 2-amino-3-thiophenecarbonitriles, ketones, and silica gel afforded smoothly the corresponding aminothieno[2,3-b]pyridine derivatives in one step. A wide variety of ketones were tested under these conditions. The reactions proceeded rapidly and afforded the desired products in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.075

文献信息

• Microwave-assisted novel synthesis of amino-thieno[3,2-b]pyridines under solvent-free conditions
  作者：Weike Su、Shaozheng Guo、Zhi Hong、Ren’er Chen

  DOI：10.1016/j.tetlet.2010.08.075

  日期：2010.10

  In the presence of a catalytic amount of ytterbium(III) triflate and under microwave irradiation, mixtures of 2-amino-3-thiophenecarbonitriles, ketones, and silica gel afforded smoothly the corresponding aminothieno[2,3-b]pyridine derivatives in one step. A wide variety of ketones were tested under these conditions. The reactions proceeded rapidly and afforded the desired products in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.