Boc-Lys(Boc)-Lys(1)-Lys(2)-OH.Boc-Lys(Boc)-Lys(3)-(2).Boc-Lys(Boc)-(1).Boc-Lys(Boc)-(3) | 135467-14-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Lys(Boc)-Lys(1)-Lys(2)-OH.Boc-Lys(Boc)-Lys(3)-(2).Boc-Lys(Boc)-(1).Boc-Lys(Boc)-(3)
• 英文别名: (2S)-2,6-bis[[(2S)-2,6-bis[[(2S)-2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]amino]hexanoyl]amino]hexanoic acid
• CAS: 135467-14-0
• 化学式: C₈₂H₁₅₀N₁₄O₂₄
• 分子量: 1716.17
• InChiKey: GDNJSXYUNOQIHO-MQEJUTFJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  120
• 可旋转键数：
  65
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  519
• 氢给体数：
  15
• 氢受体数：
  24

反应信息

• 作为反应物：
  描述：

  Boc-Lys(Boc)-Lys(1)-Lys(2)-OH.Boc-Lys(Boc)-Lys(3)-(2).Boc-Lys(Boc)-(1).Boc-Lys(Boc)-(3) 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以100%的产率得到(S)-2,6-Bis-[(S)-2,6-bis-((S)-2,6-diamino-hexanoylamino)-hexanoylamino]-hexanoic acid
  参考文献：
  名称：

  Facile synthesis of poly-(l-lysine) dendrimers with a pentaaminecobalt(III) complex at the core

  摘要：

  The synthesis of second and third generation dendrimers based on poly-(L-lysine) with a pentaamine cobalt(III) metal complex at the core is described. The synthesis and purification of these dendrimers were facilitated by using the metal complex as the C-terminal protecting group. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.06.078
• 作为产物：
  描述：

  (S)-2,6-二叔丁氧羰基氨基己酸 生成 Boc-Lys(Boc)-Lys(1)-Lys(2)-OH.Boc-Lys(Boc)-Lys(3)-(2).Boc-Lys(Boc)-(1).Boc-Lys(Boc)-(3)
  参考文献：
  名称：

  Facile synthesis of poly-(l-lysine) dendrimers with a pentaaminecobalt(III) complex at the core

  摘要：

  The synthesis of second and third generation dendrimers based on poly-(L-lysine) with a pentaamine cobalt(III) metal complex at the core is described. The synthesis and purification of these dendrimers were facilitated by using the metal complex as the C-terminal protecting group. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.06.078

文献信息

• Syntheses of dendritic branches based on l-lysine: is the stereochemistry preserved throughout the synthesis?
  作者：Malcolm Driffield、David M. Goodall、David K. Smith

  DOI：10.1039/b304410f

  日期：——

  stereochemistry in the dendritic peptide was dependent on the method of synthesis, with divergent methodology being preferred. The results are discussed in terms of the known stereochemical outcomes of traditional peptide coupling processes, and are generalised to the synthesis of other dendritic peptides. Such observations about the chirality of dendritic peptides are of relevance to chemists developing

  本文报道了基于L-赖氨酸并用Boc或Bz表面基团官能化的单个树枝状分支的合成。采用会聚和发散的合成方法，并使用旋光法，NMR和HPLC监测合成过程中立体化学的保留情况。另外，出于比较目的，合成了基于D，L-赖氨酸的外消旋树枝状分支。观察到树突状肽中立体化学的保留取决于合成方法，优选发散方法。根据传统肽偶联方法的已知立体化学结果讨论了结果，并将其推广到其他树突状肽的合成。
• Controllable mixed-charged co-assembly of dendritic lipopeptides into invisible capsid-like nanoparticles as potential drug carriers
  作者：Qinhan Xu、Chang Shu、Yachao Li、Rong Zhuang、Lei Jiang、Xianghui Xu

  DOI：10.1039/d0cc07953g

  日期：——

  A new type of molecular and supramolecular strategy is proposed to controllably construct mixed-charged nanoparticles with resistance to protein adsorption.

  提出了一种新型的分子和超分子策略，以可控的方式构建具有蛋白质吸附抗性的混合电荷纳米颗粒。
• Supramolecular dendrimer chemistry: using dendritic crown ethers to reversibly generate functional assemblies
  作者：Graham M. Dykes、David K. Smith

  DOI：10.1016/s0040-4020(03)00468-x

  日期：2003.5

  cations possessing long alkyl spacer chains as templates has also been investigated, and in this case, the 2:1 assembly that forms, goes on to achieve higher order levels of organisation, hence gelating the solvent. This particular system is therefore a rare example in which discrete, characterisable dendritic supermolecules possess an inherent potential for further supramolecular assembly, to yield new

  合成了一系列基于l-赖氨酸重复单元的具有树枝状支化功能的冠醚衍生物。已使用NMR和质谱技术研究了这些受体与阳离子客体相互作用的能力。已经评价了结合常数，其中一些使用竞争性结合测定法，并且这些结合常数表明，封装的冠醚和阳离子客体之间的相互作用强度随着树突状官能度的增加而降低。已经研究了这些树枝状分支与对位铵阳离子官能化模板的相互作用，并且作业图分析表明在MeOH溶液中形成了2：1（分支/模板）化学计量的配合物。这些超分子组装已通过添加钾阳离子而分解，因此实现了模板释放到溶液中的控制释放。该过程已通过NMR方法进行了研究，并报道了抗衡阴离子对这些研究的影响。还研究了使用具有长烷基间隔链的对位铵阳离子作为模板，在这种情况下，形成的2：1组装继续达到更高的组织水平，从而使溶剂胶凝。因此，该特定系统是一个罕见的例子，其中离散的，可表征的树枝状超分子具有进一步超分子组装的内在潜力，可以生产新材料。还研
• Supramolecular Solubilisation of Hydrophilic Dyes by Using Individual Dendritic Branches
  作者：Graham M. Dykes、Lisa J. Brierley、David K. Smith、P. Terry McGrail、Gordon J. Seeley

  DOI：10.1002/1521-3765(20011105)7:21<4730::aid-chem4730>3.0.co;2-a

  日期：2001.11.5

  Individual dendritic branches can solubilise hydrophilic dyes in apolar media. The functional group at the focal point of the dendritic branch plays a key role in the dye uptake process. Supramolecular interactions between carboxylic acid and amine groups have been shown to be effective in enabling efficient solubilisation to occur. The necessary complementarity of this interaction is further illustrated by a series of control experiments. The extent of dendritic branching (i.e. dendritic generation) plays a key role in controlling the extent of dye uptake, with higher-generation dendritic branches exhibiting more efficient uptake at lower concentrations. UV/Visible spectroscopic methods have shown that the dendritic branches, in addition to the tuning of the extent of dye uptake, also tune the optical properties of the solubilised dye and this provides further insight into the interactions occurring between the solubilised dye and the individual dendritic branches. Furthermore, it is shown that suitably functionalised dendritic branches can transport hydrophilic dyes through an apolar phase and deliver them continuously into an aqueous medium.
• Controlled Release of a Dendritically Encapsulated Template Molecule
  作者：Graham M. Dykes、David K. Smith、Gordon J. Seeley

  DOI：10.1002/1521-3773(20020902)41:17<3254::aid-anie3254>3.0.co;2-4

  日期：2002.9.2