2-[[(1S,2R)-2-(4-cyclopropylphenyl)cyclopropyl]amino]-1-(4-methylpiperazin-1-yl)ethanone

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[(1S,2R)-2-(4-cyclopropylphenyl)cyclopropyl]amino]-1-(4-methylpiperazin-1-yl)ethanone
• 化学式: C₁₉H₂₇N₃O
• 分子量: 313.4
• InChiKey: KEJFJWNFPOBVPT-MSOLQXFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods and compositions for modulating cancer stem cells
  申请人：University of Canberra

  公开号：US10220053B2

  公开（公告）日：2019-03-05

  Disclosed are compositions and methods that use lysine demethylase inhibitors for inhibiting the growth of cancer stem cells or tumor initiating cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells and/or for preventing cancer recurrence.

  所公开的是使用赖氨酸去甲基化酶抑制剂抑制癌症干细胞或肿瘤始发细胞生长、增强化疗药物或辐照对癌细胞的生物效应和/或预防癌症复发的组合物和方法。
• Compositions for Modulating Cancer Stem Cells and Uses Therefor
  申请人：University of Canberra

  公开号：US20200289437A1

  公开（公告）日：2020-09-17

  Disclosed are compositions and methods for modulating cancer stem cells. More particularly, the present invention discloses the use of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of LSD- and/or PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including non-metastatic and metastatic cancer and/or for preventing cancer recurrence.
• METHODS AND COMPOSITIONS FOR MODULATING CANCER STEM CELLS
  申请人：University of Canberra

  公开号：US20210121496A1

  公开（公告）日：2021-04-29

  Disclosed are compositions and methods that use lysine demethylase inhibitors for inhibiting the growth of cancer stem cells or tumor initiating cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells and/or for preventing cancer recurrence.