(2R)-2-[[(2R)-2-[(2-bromoacetyl)amino]propanoyl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[[(2R)-2-[(2-bromoacetyl)amino]propanoyl]amino]propanoic acid
• 化学式: C₈H₁₃BrN₂O₄
• 分子量: 281.1
• InChiKey: LSVCWUKTQRTKEW-RFZPGFLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Substituted phenazines and methods of treating cancer and bacterial diseases
  申请人：Rongved Pål

  公开号：US11046678B2

  公开（公告）日：2021-06-29

  Compounds of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds.

  式 (Ia) 或 (Ib) 的化合物，或其药学上可接受的盐、 包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。
• N-OXIDE HETEROCYCLES FOR USE IN THE TREATMENT OF CANCER AND BACTERIAL DISEASES
  申请人：Rongved, Pål

  公开号：EP3555052A1

  公开（公告）日：2019-10-23
• COMPOUNDS
  申请人：RONGVED Pål

  公开号：US20200095237A1

  公开（公告）日：2020-03-26

  The invention provides compounds of general formula (I′), and their pharmaceutically acceptable salts: wherein: Z is a group having the formula: -T-S-A-Y in which: T is a group selected from —O—, —NH—, —S—, —(XCR 7 R 8 )— (where R 7 and R 8 is independently —H or C 1-3 alkyl and X is selected from from —O—, —NH—, —S—); S is —(C═O)—, —(SO 2 )—, —(PO 2 )—; A, —O—, —NH—, —S— or —NH(CO)—, —(CR 7 R 8 X)— (where R 7 and R 8 is independently —H or C 1-3 alkyl and X is selected from from —O—, —NH—, —S—), -T-S-A- is a group susceptible to hydrolytic and/or enzymatic cleavage in vivo to leave a group selected from —OH, —NH 2 , —SH, —COOH, —CONH 2 , —O—(CR 7 R 8 )—COOH and —(CR 7 R 8 )—CONH 2 ; Y is one or more targeting groups or a lipophilic or hydrophilic group affecting the solubility in water and the biodistribution in a living organism or a living cell; R 1 -R 6 are independently selected from hydrogen, halogen (e.g. F, Cl, Br, I), lower alkyl (e.g. C 1-6 alkyl), optionally substituted with an acidic group which is —COOH, —SO 3 H, —PO 3 H 2 or —B(OH) 2 . Such compounds find particular use as anti-neoplastic and anti-infective agents.
• SUBSTITUTED PHENAZINES AND METHODS OF TREATING CANCER AND BACTERIAL DISEASES
  申请人：Rongved Pål

  公开号：US20210292313A1

  公开（公告）日：2021-09-23

  A combination product comprising a carbapenem and a compound of formula (I′), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.
• [EN] N-OXIDE HETEROCYCLES FOR USE IN THE TREATMENT OF CANCER AND BACTERIAL DISEASES<br/>[FR] HÉTÉROCYCLES N-OXYDE POUR UTILISATION DANS LE TRAITEMENT DU CANCER ET DES MALADIES BACTÉRIENNES
  申请人：UNIV OSLO

  公开号：WO2018109504A1

  公开（公告）日：2018-06-21

  The invention provides compounds of general formula (P), and their pharmaceutically acceptable salts: (Formula (I')) wherein X is an N-oxide functionality (N+-0"), or CH; Z is a group susceptible to hydrolytic and/or enzymatic cleavage in vivo to form a group selected from -OH, -COOH, -CONH2, -O-Q-COOH and -0-Q-CONH2 (where Q is a straight chained or branched alkylene group, preferably Ci-3 alkylene, e.g. methylene), and Z is optionally linked to one or more targeting groups; Ri and R2 are independently selected from hydrogen, lower alkyl (e.g. C1 -6 alkyl), halogen (e.g. F, CI, Br, I), an acidic group which is -COOH, -S03H, -P03H2 or -B(OH)2; and an aryl group (e.g. phenyl); or R] and R2, together with the intervening carbon atoms, form an optionally substituted aromatic group; each W is independently selected from lower alkyl (e.g. Ci-6 alkyl), halogen (e.g. F, CI, Br, I), OH, and an acidic group which is -COOH, -S03H, -P03H2 or -B(OH)2; and p is an integer from 0 to 3. Such compounds find particular use as anti-neoplastic and anti-infective agents.