1,2,3,5,6-Pentafluoro-4-methylcyclohexa-1,3-diene

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 1,2,3,5,6-Pentafluoro-4-methylcyclohexa-1,3-diene
• 英文别名: 1,2,3,5,6-pentafluoro-4-methylcyclohexa-1,3-diene
• 化学式: C₇H₅F₅
• 分子量: 184.11
• InChiKey: XPVDLYWAZYCWJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Method for treating neurological disorders with imidazolium and imidazolinium compounds
  申请人：Agency for Science, Technology and Research

  公开号：EP2803356A1

  公开（公告）日：2014-11-19

  There is presently provided methods for delivering a neuroprotective agent to a neural cell. The methods comprise contacting a neural cell with an imidazolium or imidazolinium compound as described herein, including an imidazolium or imidazolinium salt.

  目前提供了向神经细胞递送神经保护剂的方法。这些方法包括将神经细胞与本文所述的咪唑或咪唑啉化合物（包括咪唑盐或咪唑啉盐）接触。
• [EN] MODIFIED VIRAL COMPOSITIONS FOR VIRAL TRANSDUCTION<br/>[FR] COMPOSITIONS VIRALES MODIFIÉES POUR LA TRANSDUCTION VIRALE
  申请人：[en]LYCIA THERAPEUTICS, INC.

  公开号：WO2021263061A2

  公开（公告）日：2021-12-30

  This disclosure provides compositions and methods for delivering a viral composition to cells, e.g., for cell surface receptor-mediated uptake, and enhanced viral transduction. Viral transduction can be achieved via a modified viral composition that includes a moiety that binds to a cell surface receptor ligand. Modified viral compositions and methods for reducing levels or titers of neutralizing antibodies in a subject in need of viral therapy, e.g., gene therapy, are provided. In some embodiments, the modified viral composition includes empty viral particles that bind and internalize neutralizing autoantibodies. Modified viral compositions including empty viral particles can be administered prior to viral therapy. Also provided are pharmaceutical compositions and kits including a modified viral composition.