Amino 2,3-dimethylpent-2-enoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Amino 2,3-dimethylpent-2-enoate
• 英文别名: amino 2,3-dimethylpent-2-enoate
• 化学式: C₇H₁₃NO₂
• 分子量: 143.18
• InChiKey: IFYXEMGPQBRXCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds for Modulating TRPV3 Function
  申请人：Chong Jayhong A.

  公开号：US20100152209A1

  公开（公告）日：2010-06-17

  The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

  本申请涉及化合物和用于治疗与TRPV3相关的疼痛和其他疾病的方法。
• POLYMER POLYOL COMPOSITIONS, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING POLYURETHANE RESIN
  申请人：Sanyo Chemical Industries, Ltd.

  公开号：EP1316569A1

  公开（公告）日：2003-06-04

  A polymer polyol composition is provided, which includes a dispersion medium composed of a polyol (A), or (A) and a diluent (C), and polymer particles (B) dispersed in the dispersion medium, wherein the polymer particles (B) are formed    by polymerizing an ethylenically unsaturated compound (b) in the dispersion medium in the presence or absence of a dispersant (D), wherein at least 5 mass% of (b) comprises a terminal ethylenically-unsaturated group containing compound (b1) having a number-average molecular weight of 160 to 490 and a solubility parameter SP of 9.5 to 13, or    by polymerizing an ethylenically unsaturated compound (b) in the dispersion medium, in the presence of a dispersant, the dispersant being an unsaturated polyol having a nitrogen-containing bond, which is formed by bonding a substantially saturated polyol (a) with a monofunctional active hydrogen compound (e) having at least one polymerizable unsaturated group via a polyisocyanate (f).

  本发明提供了一种聚合物多元醇组合物，它包括由多元醇（A）或（A）和稀释剂（C）组成的分散介质，以及分散在分散介质中的聚合物颗粒（B），其中聚合物颗粒（B）是通过在有或没有分散剂（D）的情况下，在分散介质中聚合乙烯基不饱和化合物（b）而形成的。 在有或没有分散剂 (D) 的情况下，通过在分散介质中聚合乙烯基不饱和化合物 (b)，其中至少 5 质量%的 (b) 包含含有末端乙烯基不饱和基团的化合物 (b1)，该化合物的数均分子量为 160 至 490，溶解度参数 SP 为 9.5 至 13，或 在有分散剂存在的情况下，在分散介质中聚合乙烯基不饱和化合物 (b)，分散剂是一种具有含氮键的不饱和多元醇，它是通过多异氰酸酯 (f) 将基本饱和的多元醇 (a) 与具有至少一个可聚合不饱和基团的单官能团活性氢化合物 (e) 结合在一起而形成的。
• POLYOL COMPOSITION CONTAINING FINE PARTICLES DISPERSED THEREIN, PROCESS FOR PRODUCTION OF POLYMERIC POLYOLS, AND PROCESS FOR PRODUCTION OF POLYURETHANE RESINS
  申请人：Sanyo Chemical Industries, Ltd.

  公开号：EP1921113A1

  公开（公告）日：2008-05-14

  A polyol composition comprising a polyol (a) and resin fine particles (b) dispersed in the polyol (a), and a method for producing the polyol composition are provided, wherein the resin fine particles (b) are particles such that an arithmetic standard deviation by volume of a particle size distribution of the particles, derived from respective values in 85 divisions of a range of 0.020 to 2000 µm determined by a laser diffraction/scattering particle size distribution analyzer, is not more than 0.6. A resin fine particle-dispersed polyol composition that, even if the resin particles dispersed in the polyol have a small particle diameter, allows the production of a polyurethane resin having an excellent mechanical strength such as elongation at break, and a method for producing the same, are provided.

  本发明提供了一种由多元醇（a）和分散在多元醇（a）中的树脂细颗粒（b）组成的多元醇组合物，以及生产该多元醇组合物的方法，其中树脂细颗粒（b）是这样的颗粒：根据激光衍射/散射粒度分布分析仪测定的 0.020 至 2000 微米范围内 85 个分度中的各自数值得出的颗粒粒度分布的体积算术标准偏差不超过 0.6。本发明提供了一种树脂细颗粒分散多元醇组合物，即使分散在多元醇中的树脂颗粒的颗粒直径较小，也能生产出断裂伸长率等机械强度优异的聚氨酯树脂，并提供了生产这种树脂的方法。
• METHOD FOR PRODUCING POLYMER POLYOL
  申请人：Sanyo Chemical Industries, Ltd.

  公开号：EP3342825A1

  公开（公告）日：2018-07-04

  The present invention relates to a method for producing a polymer polyol (Ia), the method comprising: a first step of polymerizing a monomer-containing mixture liquid (A1) comprising a polyol (a), an ethylenically unsaturated monomer (d), a radical polymerization initiator (k), and a dispersant (e), thereby obtaining a polymer polyol intermediate (B1); and a second step of polymerizing a monomer-containing mixture liquid (A2) comprising a polyol (a), an ethylenically unsaturated monomer (d), a radical polymerization initiator (k), a dispersant (e), and a base polymer polyol (h1) that is the intermediate (B1), wherein each concentration of the ethylenically unsaturated monomer (d) in the monomer-containing mixture liquids (A1) and (A2) before the initiation of polymerization in each step is 7 mass% to 25 mass%, a polymer content in the base polymer polyol (h1) is 7 mass% to 25 mass%, a conversion ratio of the ethylenically unsaturated monomer (d) to a polymer in each step is not less than 80 mass%, a conversion rate of the ethylenically unsaturated monomer (d) into a polymer from initiation of the polymerization until the conversion ratio becomes 80 mass% is not less than 8 mass%/min, and a polymer content in a polymer polyol (Ia) obtained finally is 30 mass% to 45 mass%.

  本发明涉及一种生产聚合物多元醇（Ia）的方法，该方法包括第一步，聚合由多元醇（a）、乙烯基不饱和单体（d）、自由基聚合引发剂（k）和分散剂（e）组成的含单体混合物液体（A1），从而得到聚合物多元醇中间体（B1）；第二步：聚合包含多元醇（a）、乙烯基不饱和单体（d）、自由基聚合引发剂（k）、分散剂（e）和作为中间体（B1）的基础聚合物多元醇（h1）的含单体混合物液体（A2），其中在每一步聚合开始前，含单体混合物液体（A1）和（A2）中乙烯基不饱和单体（d）的浓度分别为 7 质量％至 25 质量％、基础聚合物多元醇 (h1) 中的聚合物含量为 7 质量％至 25 质量％，每个步骤中乙烯基不饱和单体 (d) 与聚合物的转化率不低于 80 质量％，从开始聚合到转化率达到 80 质量％，乙烯基不饱和单体 (d) 转化为聚合物的转化率不低于 8 质量％/分钟，最终得到的聚合物多元醇 (Ia) 中的聚合物含量为 30 质量％至 45 质量％。
• Polymer polyol composition, process for producing the same, and process for producing polyurethane resin
  申请人：SANYO CHEMICAL INDUSTRIES, Ltd.

  公开号：US20030004217A1

  公开（公告）日：2003-01-02

  This invention provides a polymer polyol composition (I) comprising a polyol (A) and polymer particles (B) dispersed in (A), the polymer particles (B) being formed by polymerizing an ethylenically unsaturated compound (b) in a polyol, wherein the content of (B) in (I) is from 35 to 75 mass %, based on the mass of (I), and the amount of soluble polymers (P) dissolved in (A) is not more than 5 mass %, based on the mass of (A), and provides methods for producing the polymer polyol composition (I). Further, this invention provides a method for producing a foamed or non-foamed polyurethane resin, which method comprises reacting a polyol component with a polyisocyanate component in the presence or absence of a blowing agent, wherein the above polymer polyol composition is used at least as a portion of the polyol component. A polymer polyol having a low viscosity and excellent dispersion is stability is provided even when having a high concentration of polymer particles, and is used advantageously to produce polyurethane resins having excellent 25% ILD (hardness) and compression set, or foams thereof, with good operation efficiency.

  本发明提供一种聚合物多元醇组合物 (I)，包括多元醇 (A) 和分散在 (A) 中的聚合物颗粒 (B)，聚合物颗粒 (B) 由乙烯不饱和化合物 (b) 在多元醇中聚合而成、其中，(B)在(I)中的含量为 35 至 75 质量％（以(I)的质量为基准），溶解在(A)中的可溶性聚合物(P)的量不超过 5 质量％（以(A)的质量为基准），并提供了生产聚合物多元醇组合物(I)的方法。此外，本发明还提供了一种生产发泡或非发泡聚氨酯树脂的方法，该方法包括在发泡剂存在或不存在的情况下，使多元醇组分与多异氰酸酯组分反应，其中上述聚合物多元醇组合物至少作为多元醇组分的一部分使用。这种聚合物多元醇即使在聚合物颗粒浓度较高的情况下也具有低粘度和出色的分散稳定性，可用于生产具有出色的 25% ILD（硬度）和压缩永久变形的聚氨酯树脂或其泡沫，并具有良好的操作效率。