N²-Phenyl-benzene-1,2,4-triamine | 71526-55-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N²-Phenyl-benzene-1,2,4-triamine
• 英文别名: 2-N-phenylbenzene-1,2,4-triamine
• CAS: 71526-55-1
• 化学式: C₁₂H₁₃N₃
• 分子量: 199.255
• InChiKey: OWSNXLPHOKXBBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N²-Phenyl-benzene-1,2,4-triamine 在 magnesium sulfate 作用下， 以 硝基苯 为溶剂， 反应 1.0h， 生成 2-氨基吩嗪
  参考文献：
  名称：

  Sonwane, Gajanan; Kale, Mayura; Khan, Sharuk, Indian Journal of Heterocyclic Chemistry, 2022, vol. 32, # 3, p. 393 - 399

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氯-4-硝基苯胺 在 palladium on activated charcoal 氢气 、 sodium acetate 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 21.0h， 生成 N²-Phenyl-benzene-1,2,4-triamine
  参考文献：
  名称：

  Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

  摘要：

  1-Phenylbenzimidazoles are shown to be a new class of ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR). Structure-activity relationships (SARs) are narrow, with closely related heterocycles being inactive. A systematic study of substituted 1-phenyl-benzimidazoles showed clear SARs. Substituents at the 4'- and 3'-positions of the phenyl ring are tolerated but do not significantly improve activity, while substituents at the 2'-position abolish it. Substituents in the 2-, 4-, and 7-positions of the benzimidazole ring (with the exception of 4-OH) also abolish activity. Most substituents at the 5- and B-positions maintain or increase activity, with the 5-OH, 5-OMe, 5-COMe, and 5-CO2Me analogues being >10-fold more potent than the parent 1-phenylbenzimidazole. The 5-OMe analogue was both the most potent inhibitor, and showed the highest selectivity (50-fold) between PDGFR and FGFR isolated enzymes, and also a moderately effective inhibitor (IC50 = 1.9 mu M) of PDGF-stimulated PDGFR autophosphorylation in rat aorta smooth muscle cells.

  DOI：

  10.1021/jm9804681

文献信息

• Liquid crystal aligning agent for photoalignment, liquid crystal alignment film and liquid crystal display device using it, and diamine and polymer
  申请人：JNC CORPORATION

  公开号：US10968392B2

  公开（公告）日：2021-04-06

  Provided are a liquid crystal alignment film capable of being given anisotropy through photoalignment and stable to light, and a liquid crystal display device capable of keeping a high voltage holding ratio without degradation of display quality even when exposed to strong light for a long period of time. To provide these, used is a liquid crystal aligning agent for photoalignment which contains a polymer having a structural unit containing a photoreactive structure and in which the structural unit containing a photoreactive structure undergoes chemical reaction by heating.

  提供了一种液晶取向膜，能够通过光取向获得各向异性，并且对光稳定，并且提供了一种液晶显示装置，即使长时间暴露在强光下也能保持高电压保持比率而不会降低显示质量。为了实现这些，使用了一种用于光取向的液晶取向剂，其中包含具有光反应结构的结构单元的聚合物，并且具有光反应结构的结构单元通过加热发生化学反应。
• Compound
  申请人：Vicker Nigel

  公开号：US20080114042A1

  公开（公告）日：2008-05-15

  A compound having Formula I wherein one of R 1 and R 2 is a group of the formula wherein R 4 is selected from H and hydrocarbyl, R 5 is a hydrocarbyl group and L is an optional linker group, or R 1 and R 2 together form a ring substituted with the group wherein R 3 is H or a substituent, and wherein X is selected from S, O, NR 6 and C(R 7 )(R 8 ), wherein R 6 is selected from H and hydrocarbyl groups, wherein each of R 7 and R 8 are independently selected from H and hydrocarbyl groups.

  化合物I的化学式为其中R1和R2中的一个是以下式子的基团其中R4从H和烃基中选择，R5是烃基团，L是可选的连接基团，或者R1和R2组成一个取代有以下基团的环，其中R3是H或取代基团，X从S，O，NR6和C（R7）（R8）中选择，其中R6从H和烃基团中选择，R7和R8各自独立地从H和烃基团中选择。
• LIQUID CRYSTAL ALIGNING AGENT FOR PHOTOALIGNMENT, LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY DEVICE USING IT, AND DIAMINE AND POLYMER
  申请人：JNC CORPORATION

  公开号：US20190127643A1

  公开（公告）日：2019-05-02

  Provided are a liquid crystal alignment film capable of being given anisotropy through photoalignment and stable to light, and a liquid crystal display device capable of keeping a high voltage holding ratio without degradation of display quality even when exposed to strong light for a long period of time. To provide these, used is a liquid crystal aligning agent for photoalignment which contains a polymer having a structural unit containing a photoreactive structure and in which the structural unit containing a photoreactive structure undergoes chemical reaction by heating.
• US7786152B2
  申请人：——

  公开号：US7786152B2

  公开（公告）日：2010-08-31
• [EN] HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE PI3 KINASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012107465A1

  公开（公告）日：2012-08-16

  Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.