2-ethoxy-2-phenyltetrahydrofuran | 944-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethoxy-2-phenyltetrahydrofuran
• 英文别名: 2-Ethoxy-2-phenyloxolane；2-ethoxy-2-phenyloxolane
• CAS: 944-02-5
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: IMAUNLNNAHXNEK-UHFFFAOYSA-N

物化性质

• 沸点：
  278.0±40.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethoxy-2-phenyltetrahydrofuran 在 水 作用下， 生成 γ-phenyl-γ-butyrolactone
  参考文献：
  名称：

  McClelland, Robert A.; Seaman, Esther, Canadian Journal of Chemistry, 1984, vol. 62, p. 1608 - 1612

  摘要：

  DOI：
• 作为产物：
  描述：

  4-苯基-3-丁炔-1-醇 在 3H⁽¹⁺⁾*O₄₀SiW₁₂^(4-)*C₂₀H₁₈AuNP⁽¹⁺⁾ 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以67%的产率得到2-ethoxy-2-phenyltetrahydrofuran
  参考文献：
  名称：

  Polyoxometalate-Gold(I)/H⁺ Complexes: Air-Stable, Efficient, Polyvalent, and Bifunctional Catalysts

  摘要：

  Gold(I)/H+-polyoxometalate hybrids, with general formula [POM](x-)[H](x-1)(+)[R3PAu(MeCN)](+), were synthesized and fully characterized by P-31 and Si-29 MAS or liquid NMR, FT-IR, and mass spectroscopy. All these polyoxometalate gold(I) complexes exhibited excellent catalytic activity and selectivity compared to standard homogeneous gold catalysts in a large range of reactions. The variation of the ligand and the polyoxometalate nature around gold(I) also highlighted the flexibility and the multifunctionality of such catalysts, as well as their recyclability.

  DOI：

  10.1021/acs.organomet.5b00656

文献信息

• Gold-Catalyzed Tandem Cycloisomerization−Hydroalkoxylation of Homopropargylic Alcohols
  作者：Volker Belting、Norbert Krause

  DOI：10.1021/ol061751u

  日期：2006.9.1

  The tandem cycloisomerization-hydroalkoxylation of various homopropargylic alcohols in the presence of an alcohol and a dual catalyst system, consisting of a gold precatalyst and a Bronsted acid, provides an efficient route to tetrahydrofuranyl ethers under mild reaction conditions. The reaction can be carried out in various solvents, including alcohol, with both terminal and internal alkynes as the substrate.
• Polyoxometalate-Gold(I)/H⁺ Complexes: Air-Stable, Efficient, Polyvalent, and Bifunctional Catalysts
  作者：Damien Hueber、Marie Hoffmann、Pierre de Frémont、Patrick Pale、Aurélien Blanc

  DOI：10.1021/acs.organomet.5b00656

  日期：2015.10.26

  Gold(I)/H+-polyoxometalate hybrids, with general formula [POM](x-)[H](x-1)(+)[R3PAu(MeCN)](+), were synthesized and fully characterized by P-31 and Si-29 MAS or liquid NMR, FT-IR, and mass spectroscopy. All these polyoxometalate gold(I) complexes exhibited excellent catalytic activity and selectivity compared to standard homogeneous gold catalysts in a large range of reactions. The variation of the ligand and the polyoxometalate nature around gold(I) also highlighted the flexibility and the multifunctionality of such catalysts, as well as their recyclability.
• McClelland, Robert A.; Seaman, Esther, Canadian Journal of Chemistry, 1984, vol. 62, p. 1608 - 1612
  作者：McClelland, Robert A.、Seaman, Esther

  DOI：——

  日期：——