1-amino-N-(quinolin-8-yl)cyclobutane-1-carboxamide | 1515815-56-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-amino-N-(quinolin-8-yl)cyclobutane-1-carboxamide
• 英文别名: 1-amino-N-quinolin-8-ylcyclobutane-1-carboxamide
• CAS: 1515815-56-1
• 化学式: C₁₄H₁₅N₃O
• mdl: MFCD23529256
• 分子量: 241.293
• InChiKey: VPWJGBCJRISSQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-amino-N-(quinolin-8-yl)cyclobutane-1-carboxamide 在 silver(I) acetate 、 palladium diacetate 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 44.0h， 生成 1-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)-2,4-bis(1-tosyl-1H-indol-3-yl)cyclobutane-1-carboxamide
  参考文献：
  名称：

  Applications of C–H Functionalization Logic to Cyclobutane Synthesis

  摘要：

  The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.

  DOI：

  10.1021/jo4027148
• 作为产物：
  描述：

  ethyl 1-azidocyclobutanecarboxylate 在 lithium hydroxide monohydrate 、 1-丙基磷酸酐 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 反应 84.0h， 生成 1-amino-N-(quinolin-8-yl)cyclobutane-1-carboxamide
  参考文献：
  名称：

  Applications of C–H Functionalization Logic to Cyclobutane Synthesis

  摘要：

  The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.

  DOI：

  10.1021/jo4027148

文献信息

• Applications of C–H Functionalization Logic to Cyclobutane Synthesis
  作者：Will R. Gutekunst、Phil S. Baran

  DOI：10.1021/jo4027148

  日期：2014.3.21

  The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.