(4S,7S,10R,13S,19S,22S)-13-benzyl-4-[[(2R)-1-[[(2R)-1-[[(2R)-3-carboxy-1-[[(1R)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]-22-[(3R)-3-(hex-5-ynoylamino)-4-(4-hydroxyphenyl)-2-oxobutyl]-10-[(4-hydroxyphenyl)methyl]-7-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,11,14,20-tetrazacyclotricosane-19-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4S,7S,10R,13S,19S,22S)-13-benzyl-4-[[(2R)-1-[[(2R)-1-[[(2R)-3-carboxy-1-[[(1R)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]-22-[(3R)-3-(hex-5-ynoylamino)-4-(4-hydroxyphenyl)-2-oxobutyl]-10-[(4-hydroxyphenyl)methyl]-7-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,11,14,20-tetrazacyclotricosane-19-carboxylic acid
• 化学式: C₇₃H₈₉N₉O₂₁S₃
• 分子量: 1524.7
• InChiKey: GXPCFXYEFOQPSU-VXKUDOEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  106
• 可旋转键数：
  31
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  562
• 氢给体数：
  15
• 氢受体数：
  24

文献信息

• POLYMER MICELLES CONTAINING ANTHRACYLINES FOR THE TREATMENT OF CANCER
  申请人：Sill Kevin N.

  公开号：US20100278928A1

  公开（公告）日：2010-11-04

  The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using said micelles, and compositions thereof.
• POLYMER MICELLES CONTAINING ANTHRACYCLINES FOR THE TREATMENT OF CANCER
  申请人：Intezyne Technologies, Incorporated

  公开号：US20130309277A1

  公开（公告）日：2013-11-21

  The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using said micelles, and compositions thereof.
• US8524783B2
  申请人：——

  公开号：US8524783B2

  公开（公告）日：2013-09-03
• US8524784B2
  申请人：——

  公开号：US8524784B2

  公开（公告）日：2013-09-03