2-Benzylamino-7-methyl-1,8-naphthyridine | 168099-74-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Benzylamino-7-methyl-1,8-naphthyridine
• 英文别名: 2-benzylamino-7-methyl-1,8-naphthrydine；1,8-Naphthyridine, 2-benzylamino-7-methyl-；N-benzyl-7-methyl-1,8-naphthyridin-2-amine
• CAS: 168099-74-9
• 化学式: C₁₆H₁₅N₃
• 分子量: 249.315
• InChiKey: CLWDFTMMBFGPBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  十二羰基三钌 、 2-Benzylamino-7-methyl-1,8-naphthyridine 以 苯 为溶剂， 以82%的产率得到cis-[Ru2(2-benzylaminato-7-methyl-1,8-naphthrydine)2(CO)4]
  参考文献：
  名称：

  Di- and linear tri-nuclear carbonyl ruthenium clusters containing asymmetrically bridging 2,7-disubstituted naphthyridines

  摘要：

  The diruthenium(I) complex cis- [Ru-2(bmnapy)(2)(CO)(4)] 1 was prepared by reaction of 2-benzylamino-7-methyl-1 ,8-naphthyridine (Hbmnapy) with [Ru-3(CO)(12)] in benzene. The N-1,N-2 co-ordination mode of the bridging ligands is supplemented by N-8 as an axial donor atom. In contrast, the analogous reaction with 7-methyl-1,8-naphthyridin-2-one (Hmonapy) or the corresponding 5-methyl-7-phenyl derivative (Hmopnapy) afforded the respective trinuclear clusters cis- [Ru-3(monapy)(2)(CO)(6)] 2 and cis[Ru-3(mopnapy)(2)(CO)(6)] 3, which exhibit three-atom chains with 46 valence electrons. X-Ray structural analyses demonstrate that the Ru-Ru bond distance remains effectively unchanged on going from the Ru-2 unit in 1 [2.707(1) Angstrom] to the Ru-3 sequence in 3 [average 2.701(2) Angstrom], for which an Ru-Ru-Ru angle of 168.6(3)degrees is observed.

  DOI：

  10.1039/dt9950002663
• 作为产物：
  描述：

  2-chloro-7-methyl-1,8-naphthyridine 、 苄胺 反应 8.0h， 以86%的产率得到2-Benzylamino-7-methyl-1,8-naphthyridine
  参考文献：
  名称：

  Di- and linear tri-nuclear carbonyl ruthenium clusters containing asymmetrically bridging 2,7-disubstituted naphthyridines

  摘要：

  The diruthenium(I) complex cis- [Ru-2(bmnapy)(2)(CO)(4)] 1 was prepared by reaction of 2-benzylamino-7-methyl-1 ,8-naphthyridine (Hbmnapy) with [Ru-3(CO)(12)] in benzene. The N-1,N-2 co-ordination mode of the bridging ligands is supplemented by N-8 as an axial donor atom. In contrast, the analogous reaction with 7-methyl-1,8-naphthyridin-2-one (Hmonapy) or the corresponding 5-methyl-7-phenyl derivative (Hmopnapy) afforded the respective trinuclear clusters cis- [Ru-3(monapy)(2)(CO)(6)] 2 and cis[Ru-3(mopnapy)(2)(CO)(6)] 3, which exhibit three-atom chains with 46 valence electrons. X-Ray structural analyses demonstrate that the Ru-Ru bond distance remains effectively unchanged on going from the Ru-2 unit in 1 [2.707(1) Angstrom] to the Ru-3 sequence in 3 [average 2.701(2) Angstrom], for which an Ru-Ru-Ru angle of 168.6(3)degrees is observed.

  DOI：

  10.1039/dt9950002663

文献信息

• Di- and trinuclear Pd(II) and Pt(II) complexes containing bridging 2,7-disubstituted naphthyridines
  作者：Bernhard Oskui、Markus Mintert、William S Sheldrick

  DOI：10.1016/s0020-1693(98)00411-3

  日期：1999.4

  naphthyridine H 2 donp (1,8-naphthyridin-2,7-dione) in the presence of LiOH leads to the trinuclear complexes cis -[M 3 (donp) 2 (bpy) 3 ] 2+ ( 3 ) (M=Pd) and 9 (M=Pt) with similar short M⋯M distances (2.801–2.807 A). A head/tail arrangement is once again adopted by the μ 3 -1κ O 2 :2κ N 1 :3κ N 8 bridging donp 2− dianionic ligands. Blue–green coloured 9 exhibits reversible one-electron transfer waves at E 1/2

  顺式-[M 2 L 2（bpy）2] 2+（1，2，M = Pd，L = onp-，monp-; 5，6，M = Pt，L = onp-， monp-）在头部/头中包含μ-1κN 1：2κN 8桥接单阴离子萘啶配体（Honp = 1,8-萘啶-2-one，Hmonp = 7-甲基-1,8-萘啶-2-one）尾部排列，并显示出较短的M shortM距离，范围为2.794–2.804A。[MCl 2（bpy）]与二元2,7-二取代的萘啶H 2 donp（1,8-萘啶-2,7 LiOH的存在会导致三核配合物顺式[M 3（donp）2（bpy）3] 2+（3）（M = Pd）和9（M = Pt），短M⋯M相似距离（2.801–2.807 A）。μ3-1κO 2：2κN 1：3κN 8桥接donp 2-双阴离子配体，再次采用头/尾排列。蓝绿色9在E 1/2 0.65和1处表现出可逆的单电子传递波。30
• <i>cis</i> ‐ and <i>trans</i> ‐Dimolybdenum(II) Complexes with Asymmetrically 2,7‐Disubstituted Naphthyridines as Bridging Ligands
  作者：Markus Mintert、William S. Sheldrick

  DOI：10.1002/cber.19961290615

  日期：1996.6

  Treatment of [Mo(CO)6] with Hmamnp (2-acetamido-7-methyl-1,8-naphthyridine) in diglyme at 100°C affords the mononuclear complex [Mo(CO)4(Hmamnp)] 1, an intermediate product on the reaction pathway to tetrasubstituted species of the type [Mo2L4]. A disubstituted intermediate product cis-[Mo2(mphamnp)2(OAc)2] 2 (Hmphamnp) (2-acetamido-5-methyl-7-phenyl-1,8-naphthyridine) may be isolated from the reaction

  在100°C下用二甘醇二甲醚用Hmamnp（2-乙酰氨基-7-甲基-1,8-萘啶）处理[Mo（CO）6 ]，得到单核络合物[Mo（CO）4（Hmamnp）] 1，一种中间体在反应路径上生成[Mo 2 L 4 ]型四取代物质的产物。可以从[Mo]的反应中分离出双取代的中间产物顺式-[Mo 2（mphamnp）2（OAc）2 ] 2（Hmphamnp）（2-乙酰氨基-5-甲基-7-苯基-1,8-萘啶）2（OAc）4 ]与mphamnp –在THF中。这种产物的相对稳定是共平面2-乙酰氨基取代基的空间需求的结果。2和四取代的配合物反式-[Mo 2（mbznnp）4 ] 3（Hmbznnp = 2-苄氨基-7-甲基-1,8-萘啶），顺式-[Mo 2（mphonp）4 ] 4和反式-[沫2（mphonp）4 ] 5（Hmphonp = 5-甲基-7-苯基-1,8-萘啶-2-酮）都表现出该电子者优先μ-N
• Di- and linear tri-nuclear carbonyl ruthenium clusters containing asymmetrically bridging 2,7-disubstituted naphthyridines
  作者：Markus Mintert、William S. Sheldrick

  DOI：10.1039/dt9950002663

  日期：——

  The diruthenium(I) complex cis- [Ru-2(bmnapy)(2)(CO)(4)] 1 was prepared by reaction of 2-benzylamino-7-methyl-1 ,8-naphthyridine (Hbmnapy) with [Ru-3(CO)(12)] in benzene. The N-1,N-2 co-ordination mode of the bridging ligands is supplemented by N-8 as an axial donor atom. In contrast, the analogous reaction with 7-methyl-1,8-naphthyridin-2-one (Hmonapy) or the corresponding 5-methyl-7-phenyl derivative (Hmopnapy) afforded the respective trinuclear clusters cis- [Ru-3(monapy)(2)(CO)(6)] 2 and cis[Ru-3(mopnapy)(2)(CO)(6)] 3, which exhibit three-atom chains with 46 valence electrons. X-Ray structural analyses demonstrate that the Ru-Ru bond distance remains effectively unchanged on going from the Ru-2 unit in 1 [2.707(1) Angstrom] to the Ru-3 sequence in 3 [average 2.701(2) Angstrom], for which an Ru-Ru-Ru angle of 168.6(3)degrees is observed.