benzyloxy-malonic acid diamide | 5774-54-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyloxy-malonic acid diamide
• 英文别名: Benzyloxy-malonsaeure-diamid；2-Phenylmethoxypropanediamide
• CAS: 5774-54-9
• 化学式: C₁₀H₁₂N₂O₃
• 分子量: 208.217
• InChiKey: QFAQDLBGZZBDML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  95.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苄氧乙酸 在 ammonium hydroxide 、 硫酸 、 sodium ethanolate 、 苯 作用下， 生成 benzyloxy-malonic acid diamide
  参考文献：
  名称：

  Chang; Wu, Scientia Sinica (English Edition), 1957, vol. 6, p. 279,289

  摘要：

  DOI：

文献信息

• NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1204652A1

  公开（公告）日：2002-05-15
• [EN] NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSES DE DERIVES DE SUCCINATE UTILISES COMME INHIBITEURS DES CYSTEINE PROTEASES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2001009110A1

  公开（公告）日：2001-02-08

  Disclosed are novel succinate derivative compounds of formula (I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.
• [EN] NOVEL NITRILES USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES<br/>[FR] NOUVEAUX NITRILES UTILISES COMME INHIBITEURS REVERSIBLES DE CYSTEINE PROTEASES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2002100849A2

  公开（公告）日：2002-12-19

  Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases and pathological conditions exacerbated by these proteases such as, but not limited to, osteoporosis, rheumatoid arthritis, multiple sclerosis, asthma and other autoimmune diseases, Alzheimer's disease, atherosclerosis. Also disclosed are processes for making such novel compounds.
• Chang; Wu, Scientia Sinica (English Edition), 1957, vol. 6, p. 279,289
  作者：Chang、Wu

  DOI：——

  日期：——