5-(3,4-diethoxybenzyl)thiazolidine-2,4-dione | 79524-99-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(3,4-diethoxybenzyl)thiazolidine-2,4-dione
• 英文别名: 5-((3,4-Diethoxyphenyl)methyl)-2,4-thiazolidinedione；5-[(3,4-diethoxyphenyl)methyl]-1,3-thiazolidine-2,4-dione
• CAS: 79524-99-5
• 化学式: C₁₄H₁₇NO₄S
• 分子量: 295.359
• InChiKey: IWDNIIVQLPLASA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(3,4-diethoxybenzyl)-2-iminothiazolidin-4-one 以56%的产率得到
  参考文献：
  名称：

  SOHDA, TAKASHI;MIZUNO, KATSUTOSHI;HIRATA, TAKEO;MAKI, YOSHITAKA;KAWAMATSU+, CHEM. AND PHARM. BULL., 1983, 31, N 2, 560-569

  摘要：

  DOI：

文献信息

• Antiulcer activity of 5-benzylthiazolidine-2,4-dione derivatives.
  作者：TAKASHI SOHDA、KATSUTOSHI MIZUNO、TAKEO HIRATA、YOSHITAKA MAKI、YUTAKA KAWAMATSU

  DOI：10.1248/cpb.31.560

  日期：——

  5-Benzylthiazolidine-2, 4-dione derivatives were prepared and examined for antisecretory and antiulcer activities using pylorus-ligated rats and water-immersion stress rats. Some of these compounds, in particular, 5-(2, 4, 5-tripropoxybenzyl) thiazolidine-2, 4-dione (4) and 5-(2, 4-dimethoxybenzyl) thiazolidine-2, 4-dione (23), exhibited pronounced pharmacological activities. Structure-activity relationships are discussed.

  制备了5-苄基-噻唑烷-2,4-二酮衍生物，并通过结扎大鼠幽门和水浸应激大鼠模型进行了抗分泌和抗溃疡活性的检验。其中一些化合物，尤其是5-(2, 4, 5-三丙氧基苄基)噻唑烷-2, 4-二酮（4）和5-(2, 4-二甲氧基苄基)噻唑烷-2, 4-二酮（23），表现出显著的药理活性。结构-活性关系在此进行了讨论。
• Thiazolidine derivatives use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04376777A1

  公开（公告）日：1983-03-15

  A thiazolidine derivative of the formula: ##STR1## wherein R.sub.1 is hydrogen, hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms, or lower carboxylic acyloxy having 2 to 4 carbon atoms; each of R.sub.2 and R.sub.3 is hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms or lower carboxylic acyloxy having 2 to 4 carbon atoms or pharmaceutically acceptable salt thereof a is a novel compound having antiulcer activity and inhibitory effect on gastric acid secretion. The compound is useful as antiulcer agent or inhibitory agent of gastric acid secretion.

  一种噻唑啉衍生物，其化学式为：##STR1## 其中R.sub.1是氢，羟基，1到4个碳原子的低级烷基，1到4个碳原子的低级烷氧基或2到4个碳原子的低级羧酸酰氧基；R.sub.2和R.sub.3中的每一个是羟基，1到4个碳原子的低级烷基，1到4个碳原子的低级烷氧基或2到4个碳原子的低级羧酸酰氧基，或其药学上可接受的盐，是一种具有抗溃疡活性和抑制胃酸分泌作用的新化合物。该化合物可用作抗溃疡剂或胃酸分泌抑制剂。
• Thiazolidine derivatives and their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0032128A1

  公开（公告）日：1981-07-15

  A thiazolidine derivative of the formula: wherein R is hydrogen, hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms, or lower carboxylic acyloxy having 2 to4 carbon atoms; each of R2 and R3 is hydroxyl, lower alkyl having 1 to4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms or lower carboxylic acyloxy having 2 to 4 carbon atoms or pharmaceutically acceptable salt thereof is a novel compound and having antiulcer activity and inhibitory effect of gastric acid secretion. The compound is useful as antiulcer agent or inhibitory agent of gastric acid secretion.

  式中的噻唑烷衍生物： 其中 R 是氢、羟基、具有 1 至 4 个碳原子的低级烷基、具有 1 至 4 个碳原子的低级烷氧基或具有 2 至 4 个碳原子的低级羧基酰氧基；R2 和 R3 各为羟基、具有 1 至 4 个碳原子的低级烷基、具有 1 至 4 个碳原子的低级烷氧基或具有 2 至 4 个碳原子的低级羧基酰氧基或其药学上可接受的盐，是一种新型化合物，具有抗溃疡活性和抑制胃酸分泌的作用。该化合物可用作抗溃疡剂或胃酸分泌抑制剂。
• KAWAMATSU, YUTAKA;TAKASHI, SOHDA;HIRATA, TAKEO
  作者：KAWAMATSU, YUTAKA、TAKASHI, SOHDA、HIRATA, TAKEO

  DOI：——

  日期：——
• US4376777A
  申请人：——

  公开号：US4376777A

  公开（公告）日：1983-03-15