3-Ethyl-tetrahydro-2H-1,3-oxazinon-(2) | 15833-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-Ethyl-tetrahydro-2H-1,3-oxazinon-(2)
• 英文别名: 3-ethyl-[1,3]oxazinan-2-one；3-Ethyl-1,3-oxazinan-2-one
• CAS: 15833-14-4
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: AQEKNNBYSQZCCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  光气 、 3-二乙氨基-1-丙醇 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 3-Ethyl-tetrahydro-2H-1,3-oxazinon-(2)
  参考文献：
  名称：

  2-Oxazolidinones from an N-dealkylation reaction of phosgene with dialkylaminoalkanols. Isolation and reactivities of an N-acyl quaternary ammonium intermediate

  摘要：

  DOI：

  10.1021/jo01268a014

文献信息

• [EN] HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLES SERVANT D'INHIBITEURS D'IRAK, ET LEURS UTILISATIONS
  申请人：MERCK PATENT GMBH

  公开号：WO2017049068A1

  公开（公告）日：2017-03-23

  The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.

  本发明涉及式(I)化合物及其药用可接受的组合物，作为IRAK抑制剂。
• Macrocyclic Compounds and Methods for Their Production
  申请人：Moss Steven James

  公开号：US20140038885A1

  公开（公告）日：2014-02-06

  There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.

  提供了公式（I）的化合物，可用于治疗病毒感染或作为免疫抑制剂。
• METHODS OF INHIBITING PROTEIN TYROSINE KINASE ACTIVITY
  申请人：MethylGene Inc.

  公开号：US20140179632A1

  公开（公告）日：2014-06-26

  This invention relates to methods for inhibiting kinase activity and/or inhibiting angiogenesis and/or treating a disease responsive to inhibition of kinase activity and/or treating a cell proliferative disease and/or treating an ophthalmic disease, condition or disorder treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions comprising administering novel compounds that inhibit protein tyrosine kinase activity.

  本发明涉及抑制激酶活性和/或抑制血管生成和/或治疗对抑制激酶活性有响应的疾病和/或治疗细胞增殖性疾病和/或治疗眼科疾病、情况或障碍，治疗细胞增殖性疾病和情况和眼科疾病、障碍和情况的方法，包括给予抑制蛋白酪氨酸激酶活性的新化合物。
• METHODS OF TREATMENT OF CELL PROLIFERATIVE AND/OR OPHTHALMIC DISEASES, DISORDERS AND CONDITIONS USING INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY
  申请人：MethylGene Inc.

  公开号：US20140315801A1

  公开（公告）日：2014-10-23

  This invention relates to methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions using compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to the methods of treatment which utilize compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling.

  本发明涉及使用抑制蛋白酪氨酸激酶活性的化合物治疗细胞增殖性疾病和病况以及眼科疾病、障碍和病况的方法。特别地，本发明涉及使用抑制生长因子受体蛋白酪氨酸激酶活性的化合物的治疗方法，从而抑制受体信号传导，例如抑制VEGF受体信号传导。
• HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
  申请人：Berger Richard

  公开号：US20110028461A1

  公开（公告）日：2011-02-03

  The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

  本发明提供了I式化合物，其药物组成物以及使用该组成物的方法，用于治疗或预防通过激活β3肾上腺素受体介导的疾病。