N,3-dihydroxy-2-(3-phenylprop-2-enoylamino)propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,3-dihydroxy-2-(3-phenylprop-2-enoylamino)propanamide
• 化学式: C₁₂H₁₄N₂O₄
• 分子量: 250.25
• InChiKey: SPSMKKMVMBXFRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
  申请人：Clauzel Marti Luc

  公开号：US20070066646A1

  公开（公告）日：2007-03-22

  This invention is directed to inhibitors of copper-containing amine oxidases (E.C. 1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein-1, VAP-1), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.

  这项发明涉及铜含量胺氧化酶（E.C. 1.4.3.6）的抑制剂，包括半胱氨酸敏感胺氧化酶（SSAO；也称为血管粘附蛋白-1，VAP-1），以及它们在炎症性疾病、糖尿病及其相关并发症、动脉粥样硬化、神经退行性疾病、肥胖症、高血压和癌症中的治疗用途。
• COMPOUNDS FOR INHIBITING COPPER-CONTAINING AMINE OXIDASES AND USES THEREOF
  申请人：Genmedica Therapeutics SL

  公开号：EP1796681A2

  公开（公告）日：2007-06-20
• [EN] COMPOUNDS FOR INHIBITING COPPER-CONTAINING AMINE OXIDASES AND USES THEREOF<br/>[FR] COMPOSES INHIBANT LES AMINE OXYDASES CONTENANT DU CUIVRE, ET UTILISATIONS CORRESPONDANTES
  申请人：GENMEDICA THERAPEUTICS SL

  公开号：WO2006013209A2

  公开（公告）日：2006-02-09

  This invention is directed to inhibitors of copper-containing amine oxidases (E.C.1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein- 1, VAP-I), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.