(3S)-1-[(2S,3S)-2-azido-3-(4-bromophenyl)-4-cyclopropylbutanoyl]-3-fluoropyrrolidine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-1-[(2S,3S)-2-azido-3-(4-bromophenyl)-4-cyclopropylbutanoyl]-3-fluoropyrrolidine
• 英文别名: (2S,3S)-2-azido-3-(4-bromophenyl)-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one
• 化学式: C₁₇H₂₀BrFN₄O
• 分子量: 395.274
• InChiKey: WNEXSAHFMQEIOQ-JYJNAYRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  34.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Phenylalanine derivatives as depeptidyl peptidase inhibitors for the treatment or prevention of diabetes
  申请人：Colandrea J. Vincent

  公开号：US20050222140A1

  公开（公告）日：2005-10-06

  The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及苯丙氨酸衍生物，它们是二肽酶-IV酶（“DP-IV抑制剂”）的抑制剂，可用于治疗或预防二肽酶-IV酶参与的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗二肽酶-IV酶参与的疾病中的使用。
• PHENYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  申请人：Merck & Co., Inc.

  公开号：EP1562925B1

  公开（公告）日：2007-01-03
• US7157490B2
  申请人：——

  公开号：US7157490B2

  公开（公告）日：2007-01-02