5-hydroxy-2-(1-hydroxyoctyl)-3-oxo-12-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyl-2-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxan-2-yl]dodecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-hydroxy-2-(1-hydroxyoctyl)-3-oxo-12-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyl-2-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxan-2-yl]dodecanoic acid
• 化学式: C₃₂H₅₈O₁₃
• 分子量: 650.8
• InChiKey: FMXUDHIMPVCLLL-RUHVPANASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  45
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  235
• 氢给体数：
  9
• 氢受体数：
  13

文献信息

• PROCESS FOR PRODUCING A RHAMNOLIPID PRODUCED BY PSEUDOMONAS OR ENTEROBACTER USING ANDIROBA OR MURUMURU SEED WASTE
  申请人：Natura Cosméticos S.A.

  公开号：EP3569714A1

  公开（公告）日：2019-11-20

  The process for obtaining rhamnolipids from Pseudomonas aeruginosa or Enterobacter using andiroba or murumuru seed residue belonging to the field of monosaccharide radical-containing compounds consists of obtaining rhamnolipids by means of a biotechnological process that uses andiroba or murumuru seed residues after extraction of the oil thereof as a substrate for Pseudomonas aeruginosa or Enterobacter hormaechei or Enterobacter buriae strains cultured in a bioreactor in a non-dispersive aeration system to reduce foaming, hence obtaining a rhamnolipid content of 10.5 g/L for Pseudomonas aeruginosa in stirred tank bioreactors under non-dispersive aeration, using microporous membranes, particularly silicone tubes, which allow oxygen supply by diffusion. This type of aeration allows for different configurations to be used, and in the exemplary embodiment of the invention the porous membrane/tube was located internally into the bioreactor liquor in the shape of a coil under the following process conditions: pure oxygen with pressure and flow rate suitable to maintain the O2 pressure in the bioreactor at 20% over the first 24 hours of the assay and stirring in the range of from 300 to 700 rpm, using 2 radial impellers and manual configurations made as the dissolved oxygen concentration decreases. The obtained product has characteristics that cause it to be applied in the cosmetics industry owing to its emulsifying ability, stability and non-toxicity.

  利用属于单糖基化合物领域的安地罗巴或榈木籽残渣从铜绿假单胞菌或肠杆菌中获得鼠李糖脂的工艺包括通过生物技术工艺获得鼠李糖脂，该工艺利用提取其油后的安地罗巴或榈木籽残渣作为铜绿假单胞菌或肠杆菌的底物。本发明的目的是通过一种生物技术工艺获得鼠李糖脂，该工艺使用提取其油后的安地罗巴或榈木籽残渣作为底物，用于在非分散曝气系统中的生物反应器中培养铜绿假单胞菌或荷尔玛氏肠杆菌或布氏肠杆菌菌株，以减少起泡、因此，假单胞菌的鼠李糖脂含量为 10.铜绿假单胞菌在非分散曝气条件下的搅拌罐生物反应器中的鼠李糖脂含量为 5 克/升，该反应器使用微孔膜，特别是硅胶管，可通过扩散提供氧气。这种曝气方式可以使用不同的配置，在本发明的示范性实施方案中，多孔膜/管以线圈的形状位于生物反应器液的内部，工艺条件如下：纯氧，压力和流速适合在测定的头 24 小时内将生物反应器中的氧气压力维持在 20%，搅拌转速范围为 300 至 700 转/分钟，使用 2 个径向叶轮，随着溶解氧浓度的降低进行手动配置。 获得的产品具有乳化能力、稳定性和无毒性等特点，可用于化妆品行业。
• Materials derived from fermentation-produced rhamnolipids and methods of production
  申请人：Ju Lu-Kwang

  公开号：US10344304B2

  公开（公告）日：2019-07-09

  A method of preparing a product derived from a rhamnolipid includes the steps of: providing a rhamnolipid, combining the rhamnolipid with a reagent, allowing the rhamnolipid and reagent to react to form a product derived from the rhamnolipid, and collecting the product derived from the rhamnolipid. An exemplary product is dimeric β-hydroxy fatty acid.

  一种制备鼠李糖脂衍生产物的方法包括以下步骤：提供鼠李糖脂，将鼠李糖脂与试剂结合，使鼠李糖脂和试剂反应形成鼠李糖脂衍生产物，收集鼠李糖脂衍生产物。一种示例性产物是二聚 β-羟基脂肪酸。
• Process for producing a rhamnolipid produced by Pseudomonas or Enterobacter using andiroba or murumuru seed waste
  申请人：Natura Cosmeticos S/A

  公开号：US10801053B2

  公开（公告）日：2020-10-13

  Process for producing a rhamnolipid produced by Pseudomonas or Enterobacter using andiroba or murumuru seed waste, pertaining to the sector of compounds containing monosaccharide radicals, consists of producing rhamnolipids by a biotechnological process using andiroba or murumuru seed waste, following oil extraction, as a substrate for a Pseudomonas aeruginosa, Enterobacter hormaechei or Enterobacter buriae line cultivated in a bioreactor with a non-dispersive aeration system for reducing foam, producing a rhamnolipid content of 10.5 g/L for Pseudomonas aeruginosa bacteria, in bioreactors carried out in a stirred tank with non-dispersive aeration using microporous membranes, particularly of silicone tubes, which allow oxygen to be supplied by diffusion. This type of aeration allows for various configurations, and in the embodiment of the invention, the porous membrane/tube was internally located in the liquid in the bioreactor in the form of a serpentine, under the following process conditions: pure oxygen with suitable pressure and flow rate to maintain O2 pressure in the bioreactor at 20% during the first 24 hours of the assay and stirring varying from 300 to 700 rpm, using 2 radial impellers and manual adjustment according to the decrease in the concentration of dissolved oxygen. The product produced has features that can be used primarily in the cosmetic industry due to its emulsifying, stability and non toxicity capacities.

  由假单胞菌或肠杆菌利用安地罗巴或榈木种子废料生产鼠李糖脂的工艺，属于含单糖基化合物领域，包括利用安地罗巴或榈木种子废料的生物技术工艺生产鼠李糖脂、以铜绿假单胞菌（Pseudomonas aeruginosa）、荷尔蒙肠杆菌（Enterobacter hormaechei）或布氏肠杆菌（Enterobacter buriae）为底物，在生物反应器中通过非分散曝气系统减少泡沫，生产鼠李糖脂，其中铜绿假单胞菌（Pseudomonas aeruginosa）的鼠李糖脂含量为 10.铜绿假单胞菌（Pseudomonas aeruginosa bacteria）的鼠李糖脂含量为 5 克/升，在搅拌罐的生物反应器中进行，采用微孔膜（特别是硅胶管）进行非分散曝气，通过扩散提供氧气。在本发明的实施方案中，多孔膜/管以蛇形的形式位于生物反应器中的液体内部，其工艺条件如下：纯氧，适当的压力和流量，使生物反应器中的氧气压力在测定的头 24 小时内保持在 20%，搅拌速度从 300 转/分到 700 转/分不等，使用 2 个径向叶轮，根据溶解氧浓度的下降进行手动调节。生产出的产品具有乳化、稳定和无毒等特点，可主要用于化妆品行业。
• NOVEL MATERIALS DERIVED FROM FERMENTATION-PRODUCED RHAMNOLIPIDS AND METHODS OF PRODUCTION
  申请人：Ju Lu-Kwang

  公开号：US20170175151A1

  公开（公告）日：2017-06-22

  A method of preparing a product derived from a rhamnolipid includes the steps of: providing a rhamnolipid, combining the rhamnolipid with a reagent, allowing the rhamnolipid and reagent to react to form a product derived from the rhamnolipid, and collecting the product derived from the rhamnolipid. An exemplary product is dimeric β-hydroxy fatty acid.
• RHAMNOLIPID BASED BIOPESTICIDES
  申请人：Ju Lu-Kwang

  公开号：US20170265468A1

  公开（公告）日：2017-09-21

  A biopesticide composition includes a solvent and a plurality of rhamnolipid complexes, each rhamnolipid complex including a rhamnolipid complexed with a cation. The biopesticide composition may include a slower-releasing rhamnolipid-based material and a faster-releasing rhamnolipid-based material. The biopesticide composition may be in the form of a coating or a pellet.