(5-bromo-pyrazin-2-yl)-(1,3-dimethyl-1H-pyrazol-4-ylmethyl)amine | 945978-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (5-bromo-pyrazin-2-yl)-(1,3-dimethyl-1H-pyrazol-4-ylmethyl)amine
• 英文别名: 5-bromo-N-[(1,3-dimethylpyrazol-4-yl)methyl]pyrazin-2-amine
• CAS: 945978-42-7
• 化学式: C₁₀H₁₂BrN₅
• 分子量: 282.143
• InChiKey: HKEIVRCTOYZHLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-5-溴吡嗪 、 1,3-二甲基-1H-吡唑-4-甲醛 以 溶剂黄146 为溶剂， 以93%的产率得到(5-bromo-pyrazin-2-yl)-(1,3-dimethyl-1H-pyrazol-4-ylmethyl)amine
  参考文献：
  名称：

  METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN

  摘要：

  公开了影响胃肠动力和胃排空的方法和化合物，包括在需要的患者中抑制色氨酸羟化酶（TPH）。

  公开号：

  US20090029993A1

文献信息

• Multicyclic amino acid derivatives and methods of their use
  申请人：Devasagayaraj Arokiasamy

  公开号：US20070191370A1

  公开（公告）日：2007-08-16

  Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

  公式I和II的化合物已被披露，以及包含它们的组合物和它们的使用方法，用于治疗、预防和管理与血清素介导的疾病和紊乱：
• METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN
  申请人：Liu Qingyun

  公开号：US20090029993A1

  公开（公告）日：2009-01-29

  Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.

  公开了影响胃肠动力和胃排空的方法和化合物，包括在需要的患者中抑制色氨酸羟化酶（TPH）。
• METHODS OF USING AND COMPOSITIONS COMPRISING TRYPTOPHAN HYDROXYLASE INHIBITORS
  申请人：Brown Philip Manton

  公开号：US20090005382A1

  公开（公告）日：2009-01-01

  Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.

  公开了包含色氨酸羟化酶抑制剂的方法和组合物。特定方法旨在减少或避免与某些药物相关的通过血清素介导的不良反应。
• Methods and Compositions for Treating Pulmonary Hypertension and Related Diseases and Disorders
  申请人：Sands Arthur T.

  公开号：US20090054308A1

  公开（公告）日：2009-02-26

  Methods of treating pulmonary hypertension are disclosed. Particular methods comprise the administration of a tryptophan hydroxylase inhibitor and at least one other active pharmaceutical ingredient to patient in need thereof. Pharmaceutical formulations are also disclosed.

  公开了治疗肺动脉高压的方法。具体方法包括向需要治疗的患者施用色氨酸羟化酶抑制剂和至少一种其他活性药物成分。还公开了制药配方。
• MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE
  申请人：Devasagayaraj Arokiasamy

  公开号：US20100280054A1

  公开（公告）日：2010-11-04

  Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

  公开了化学式I和II的化合物，以及包含它们的组合物和使用它们治疗、预防和管理血清素介导的疾病和障碍的方法。