2-(N-cyclopropylanilino)butanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(N-cyclopropylanilino)butanamide
• 化学式: C₁₃H₁₈N₂O
• 分子量: 218.29
• InChiKey: OLNOSDFCFQAYDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR
  申请人：University of Canberra

  公开号：EP3509627A1

  公开（公告）日：2019-07-17
• ENHANCING T-CELL FUNCTION AND TREATING A T-CELL DYSFUNCTIONAL DISORDER WITH A COMBINATION OF AN LSD INHIBITOR AND A PD1 BINDING ANTAGONIST
  申请人：Epiaxis Therapeutics Pty Ltd

  公开号：EP3716963A1

  公开（公告）日：2020-10-07
• [EN] LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR<br/>[FR] INHIBITEURS DE L'HISTONE DÉMÉTHYLASE-1 SPÉCIFIQUES DE LA LYSINE ET LEURS UTILISATIONS
  申请人：UNIV CANBERRA

  公开号：WO2018045422A1

  公开（公告）日：2018-03-15

  Disclosed are lysine specific histone demethylase-1 (LSD1) inhibitors in methods and compositions for immune checkpoint inhibition. The invention also relates to proteinaceous molecules and their use in altering at least one of (i) formation, (ii) 5 proliferation, (iii) maintenance, (iv) epithelial to mesenchymal cell transition (EMT), or (v) mesenchymal to epithelial cell transition (MET) of an LSD1 overexpressing cell.