Thr-Phe | 5152-98-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Thr-Phe
• 英文别名: (2S)-2-[[(2S)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoic acid
• CAS: 5152-98-7；16875-27-7
• 化学式: C₁₃H₁₈N₂O₄
• 分子量: 266.297
• InChiKey: IQHUITKNHOKGFC-CSUXEGHOSA-N

物化性质

• 沸点：
  580.3±50.0 °C(Predicted)
• 密度：
  1.282±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Process for producing dipeptides
  申请人：Hashimoto Shin-ichi

  公开号：US20050287626A1

  公开（公告）日：2005-12-29

  The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the ability to produce at least one of said one or more kinds of amino acids, allowing the dipeptide to form and accumulate in the medium, and recovering the dipeptide from the medium.

  本发明提供了一种生产二肽的方法，包括在培养基中培养一种具有产生具有形成该二肽活性的蛋白质的能力的微生物，该蛋白质可以从一种或多种氨基酸中形成该二肽的能力，并且具有产生所述一种或多种氨基酸中至少一种的能力，使二肽在培养基中形成并积累，并从培养基中回收二肽。
• PROCESS FOR PRODUCING DIPEPTIDES
  申请人：Hashimoto Shin-ichi

  公开号：US20090269806A1

  公开（公告）日：2009-10-29

  The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the ability to produce at least one of said one or more kinds of amino acids, allowing the dipeptide to form and accumulate in the medium, and recovering the dipeptide from the medium.

  本发明提供了一种生产二肽的方法，包括在培养基中培养具有从一种或多种氨基酸中形成二肽的活性蛋白质产生能力和至少一种所述一种或多种氨基酸的产生能力的微生物，使二肽在培养基中形成和积累，并从培养基中回收二肽。
• METHOD FOR PRODUCING DIPEPTIDE
  申请人：Kyowa Hakko Bio Co., Ltd.

  公开号：EP2143786A1

  公开（公告）日：2010-01-13

  The present invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of a protein to transport a dipeptide in a microbial cell to the outside of the microbial cell (hereinafter to be referred to as a dipeptide transporting activity) is higher than that of a parental strain, wherein said protein having a dipeptide transporting activity is described in any of the following [1] to [3]: [1] a protein having an amino acid sequence shown by any of SEQ ID NOs: 6 to 10 [2] a protein having an amino acid sequence wherein one or more amino acids are deleted, substituted or added in the amino acid sequence shown by any of SEQ ID NOs: 6 to 10, and having a dipeptide transporting activity, [3] a protein having an amino acid sequence having 80% or more homology with the amino acid sequence shown by any of SEQ ID NOs: 6 to 10, and having a dipeptide transport activity, and a process of producing dipeptide using the microorganism.

  本发明提供了一种微生物，该微生物具有产生具有二肽合成活性的蛋白质的能力，并且其中的蛋白质将微生物细胞内的二肽转运到微生物细胞外的活性（以下称为二肽转运活性）高于亲本菌株，其中所述具有二肽转运活性的蛋白质在以下[1]至[3]中任一项中描述： [1] 具有 SEQ ID NOs: 6 至 10 中任意一个所示氨基酸序列的蛋白质 [2]一种具有氨基酸序列的蛋白质，其中一个或多个氨基酸在 SEQ ID NO：6 至 10 中任一个所示的氨基酸序列中被删除、取代或添加，并具有二肽转运活性、 [3] 一种蛋白质，其氨基酸序列与 SEQ ID NOs: 6 至 10 中任意一个所示的氨基酸序列具有 80% 或以上的同源性，并具有二肽转运活性，以及一种使用该微生物生产二肽的工艺。
• ENTERAL PREPARATION FOR CANCER THERAPY
  申请人：OTSUKA PHARMACEUTICAL FACTORY, INC.

  公开号：EP0560989B1

  公开（公告）日：1999-09-01
• US5658895A
  申请人：——

  公开号：US5658895A

  公开（公告）日：1997-08-19