6-(乙酰氨基)-己酸琥珀酰亚胺酯 | 105612-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 6-(乙酰氨基)-己酸琥珀酰亚胺酯
• 中文别名: 乙酰胺,N-[6-[(2,5-二羰基-1-吡咯烷基)氧代]-6-羰基己基]-
• 英文名称: 6-(acetylamino)-hexanoic acid succinimidyl ester
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 6-acetamidohexanoate
• CAS: 105612-00-8
• 化学式: C₁₂H₁₈N₂O₅
• 分子量: 270.285
• InChiKey: KVPZOOONPHNXET-UHFFFAOYSA-N

物化性质

• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  92.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-(乙酰氨基)-己酸琥珀酰亚胺酯 、 D-丙氨酰-D-丙氨酸 在 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 反应 4.0h， 以49%的产率得到(2R)-2-[[(2R)-2-(6-acetamidohexanoylamino)propanoyl]amino]propanoic acid
  参考文献：
  名称：

  Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor

  摘要：

  Four small molecular receptors of vancomycin have been designed to make part of a novel biosensor device based on the FTIR-ATR detection: N-Boc (2a) or N-Ac (2b)-6-aminocaproyl-D-Ala-D-Ala and N-Boc (3a) or N-Ac (3b)-6-aminocaproyl-D-Ala-D-Ser. Using an original microbiological approach to assess the competition of compounds with the natural target of vancomycin in bacteria, EC50 values of 6.3-8.0 x 10(-5) M (2a-b) and 7.1-9.3 x 10(-4) M (3a-b) were determined. Vancomycin:2b complex was characterized by MS. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.08.055
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 醋氨己酸 在 4-二甲氨基吡啶 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以62%的产率得到6-(乙酰氨基)-己酸琥珀酰亚胺酯
  参考文献：
  名称：

  Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor

  摘要：

  Four small molecular receptors of vancomycin have been designed to make part of a novel biosensor device based on the FTIR-ATR detection: N-Boc (2a) or N-Ac (2b)-6-aminocaproyl-D-Ala-D-Ala and N-Boc (3a) or N-Ac (3b)-6-aminocaproyl-D-Ala-D-Ser. Using an original microbiological approach to assess the competition of compounds with the natural target of vancomycin in bacteria, EC50 values of 6.3-8.0 x 10(-5) M (2a-b) and 7.1-9.3 x 10(-4) M (3a-b) were determined. Vancomycin:2b complex was characterized by MS. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.08.055

文献信息

• Fluorescent compounds that bind to histone deacetylase
  申请人：Heidebrecht, JR. Richard W.

  公开号：US20090156825A1

  公开（公告）日：2009-06-18

  The present invention relates to a novel class of fluorescent compounds that bind to histone deacetylases. The fluorescent compounds can be used to determine binding association and dissociation rates of histone deacetylase inhibitors via fluorescence polarization.

  本发明涉及一种新型荧光化合物类，其与组蛋白去乙酰化酶结合。这些荧光化合物可用于通过荧光偏振确定组蛋白去乙酰化酶抑制剂的结合关联和解离速率。
• REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO
  申请人：Beachy Philip A.

  公开号：US20110263519A1

  公开（公告）日：2011-10-27

  The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.

  本发明提供了调节平滑蛋白依赖性通路激活的方法和试剂等。在某些实施例中，所述方法可用于对抗由于刺猬增强功能、ptc失去功能或平滑蛋白增强功能突变引起的刺猬通路不必要激活的表型效应。
• Living Copolymer-Protein/Peptide Hybrids for Biomedical Applications
  申请人：Raja Krishnaswami

  公开号：US20110262991A1

  公开（公告）日：2011-10-27

  Water soluble polymers having formula I: Y-(L 1 ) ni -(C(O)) n2 —(R 1 ) n3 —R 2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.

  具有I式的水溶性聚合物：Y-(L1)ni-(C（O）)n2—（R1）n3—R2被声明。这些聚合物可以包含多个水溶性、免疫原性降低的基团和多个活性基团。这些聚合物可以与具有多达十二个氨基酸的蛋白质或肽连接。
• NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES
  申请人：RWTH Aachen

  公开号：EP1874790B1

  公开（公告）日：2010-08-18
• Methods for the detection of colorectal cancer
  申请人：Gite Sadanand

  公开号：US20070003936A1

  公开（公告）日：2007-01-04

  This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated and analyzed without the handling and disposal problems associated with radioactive reagents. Preferred markers are dipyrrometheneboron difluoride (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) dyes.